Restoring Immunity Across the Human Lifespan and in High-Risk Groups

Divergent cytokine and transcriptional signatures control functional T follicular helper cell heterogeneity

L Dalit, CW Tan, AA Sheikh, R Munnings, LJ Howson, C Alvarado, T Hussain, A Zaini, L Cooper, A Kirn, L Hailes, A Nguyen, BE Williams, MZM Zheng, CE van de Sandt, LK Mackay, KL Flanagan, K Kedzierska, N Harris, JA Juno

2025-10-01

CD4⁺ T follicular helper (T<inf>FH</inf>) cells support tailored B cell responses against multiple classes of pathogens..

Central memory T cells with key TCR repertoires and gene expression profiles dominate influenza CD8 T cell pools across the human lifespan

T Menon, HA McQuilten, J Samir, THO Nguyen, R Lim, J Kaur, S Rizzetto, A Eltahla, PG Thomas, M Lappas, J Rossjohn, S Gras, J Crowe, KL Flanagan, F Luciani, PC Doherty, CE van de Sandt, K Kedzierska

2025-07-29

Central memory CD8⁺ T cells (T<inf>cm</inf>) represent the prominent memory T cell subset in human blood, yet the persi..