Stress in Epilepsy: Relating Multiday Cycles of Seizure Risk and the Autonomic Nervous System to Deliver Novel Epilepsy Management.

Tracking seizure cycles beats a prospective moving average: Commentary on "Rigorous evaluation of five e-diary alone seizure forecasting tools"

RE Stirling, BH Brinkmann, DR Freestone, PJ Karoly

2026-04-01

There is debate on the predictive value of multiday seizure cycles versus simple statistical baselines. Multidien seizure cyclicit..

Time to Change the Drug Trial Paradigm for Dravet Syndrome: Designing Trials for the Disease Rather than Squeezing the Disease into the Trial

IE Scheffer, P Perucca, PJ Karoly

2026-03-01

Drug trial design is at an inflection point in epilepsy and neurological disorders. We are moving from conventional parallel-group..