New Strategies to Improve Personalized Immunotherapy of Breast Cancer.

Targeting Tumor Heterogeneity with Neoantigen-Based Cancer Vaccines

S Pounraj, S Chen, L Ma, R Mazzieri, R Dolcetti, BHA Rehm

2024-02-01

Neoantigen-based cancer vaccines have emerged as a promising immunotherapeutic approach to treat cancer. Nevertheless, the high de..

Skin-Grafting and Dendritic Cell “Boosted” Humanized Mouse Models Allow the Pre-Clinical Evaluation of Therapeutic Cancer Vaccines

B Zeng, D Moi, L Tolley, N Molotkov, IH Frazer, C Perry, R Dolcetti, R Mazzieri, JLG Cruz

2023-08-01

Vaccines have been hailed as one of the most remarkable medical advancements in human history, and their potential for treating ca..

Weaponizing natural killer cells for solid cancer immunotherapy

JKM Wong, R Dolcetti, H Rhee, F Simpson, F Souza-Fonseca-Guimaraes

2023-02-01

Enhancing natural killer (NK) cell-based innate immunity has become a promising strategy for immunotherapy against hard-to-cure so..

Multiparametric flow cytometry to characterize vaccine-induced polyfunctional T cell responses and T cell/NK cell exhaustion and memory phenotypes in mouse immuno-oncology models

D Moi, B Zeng, SA Minnie, R Bhatt, J Wood, DP Sester, R Mazzieri, R Dolcetti

2023-01-01

Suitable methods to assess in vivo immunogenicity and therapeutic efficacy of cancer vaccines in preclinical cancer models are cri..

Protein glycosylation in head and neck cancers: From diagnosis to treatment

M Rasheduzzaman, A Kulasinghe, R Dolcetti, L Kenny, NW Johnson, D Kolarich, C Punyadeera

2020-12-01

Glycosylation is the most common post-translational modification (PTM) of proteins. Malignant tumour cells frequently undergo an a..

Will next-generation immunotherapy overcome the intrinsic diversity and low immunogenicity of sarcomas to improve clinical benefit?

HY Chew, V Chan, F Simpson, R Dolcetti

2020-11-01

Sarcomas are a rare type of a heterogeneous group of tumours arising from mesenchymal cells that form connective tissues. Surgery ..

Editorial: Dendritic Cell-Based Immunotherapy in Solid and Haematologic Tumors

R Dolcetti, A López-Soto, J Dal Col

2020-03-31

Enhancing chimeric antigen receptor T-cell immunotherapy against cancer using a nanoemulsion-based vaccine targeting cross-presenting dendritic cells

JD Chan, B von Scheidt, B Zeng, AJ Oliver, AS Davey, AI Ali, R Thomas, JA Trapani, PK Darcy, MH Kershaw, R Dolcetti, CY Slaney

2020-01-01

Objectives: Adoptive transfer of chimeric antigen receptor (CAR)-modified T cells is a form of cancer immunotherapy that has achie..

Dissecting the multiplicity of immune effects of immunosuppressive drugs to better predict the risk of de novo malignancies in solid organ transplant patients

M Cangemi, B Montico, DA Faè, A Steffan, R Dolcetti

2019-01-01

De novo malignancies constitute an emerging cause of morbidity after solid organ transplant (SOT), significantly affecting the lon..

Plasticity of type I interferon-mediated responses in cancer therapy: From anti-tumor immunity to resistance

M Budhwani, R Mazzieri, R Dolcetti

2018-08-21

The efficacy of several therapeutic strategies against cancer, including cytotoxic drugs, radiotherapy, targeted immunotherapies a..