NOVEL TOOLS FOR THE IMAGING OF TUMOR HYPOXIA USING PET
Grant number: 469002 | Funding period: 2008 - 2011
Fast growing tumors often outgrow the ability of blood vessels to properly supply them with nutrients and oxygen. This creates tissue areas within the tumor that are lacking oxygen and are highly resistant to radiotherapy and chemotherapy. Imaging these areas using nuclear medicine techniques has now become important for therapy planning of cancer sufferers. This project aims to improve the properties of the existing agents in order to better select patients for a particular type of treatment.
Related publications (1)
Radio labelling and evaluation of novel haloethylsulfoxides as PET imaging agents for tumor hypoxia
Evelyn Laurens, Shinn Dee Yeoh, Angela Rigopoulos, Diana Cao, Glenn A Cartwright, Graeme J O'Keefe, Henri J Tochon-Danguy, Jonathan M White, Andrew M Scott, Uwe Ackermann
The significance of imaging hypoxia with the PET ligand [(18)F]FMISO has been demonstrated in a variety of cancers. However, the s..