COLORECTAL CANCER - MOLECULAR BASIS TO TARGETED THERAPEUTICS
Grant number: 487922 | Funding period: 2009 - 2013
Cancer of the colon and rectum is the most common form of cancer in Australia. Over 12,000 people are diagnosed each year with colorectal cancer (CRC) and more than one third of people will die of their disease. CRC is caused by mistakes in production of colon cells. Our research aims to discover new ways to detect CRC, develop smart drugs and nanoparticle delivery systems for destroying all types of CRC cells. We will then test our new anti-cancer drugs in clinical trials with CRC patients.
Related publications (20)
Differential Roles of the Protein Corona in the Cellular Uptake of Nanoporous Polymer Particles by Monocyte and Macrophage Cell Lines
Yan Yan, Katelyn T Gause, Marloes MJ Kamphuis, Ching-Seng Ang, Neil M O'Brien-Simpson, Jason C Lenzo, Eric C Reynolds, Edouard C Nice, Frank Caruso
Many biomolecules, mainly proteins, adsorb onto polymer particles to form a dynamic protein corona in biological environments. The..
Particles on the Move: Intracellular Trafficking and Asymmetric Mitotic Partitioning of Nanoporous Polymer Particles
Yan Yan, Zon W Lai, Robert JA Goode, Jiwei Cui, Tess Bacic, Marloes MJ Kamphuis, Edouard C Nice, Frank Caruso
Nanoporous polymer particles (NPPs) prepared by mesoporous silica templating show promise as a new class of versatile drug/gene de..
Targeting Cancer Cells: Controlling the Binding and Internalization of Antibody-Functionalized Capsules
Angus PR Johnston, Marloes MJ Kamphuis, Georgina K Such, Andrew M Scott, Edouard C Nice, Joan K Heath, Frank Caruso
The development of nanoengineered particles, such as polymersomes, liposomes, and polymer capsules, has the potential to offer sig..
Macromolecule Functionalization of Disulfide-Bonded Polymer Hydrogel Capsules and Cancer Cell Targeting
Olga Shimoni, Almar Postma, Yan Yan, Andrew M Scott, Joan K Heath, Edouard C Nice, Alexander N Zelikin, Frank Caruso
We present a generic and versatile method for functionalization of disulfide-stabilized PMA hydrogel capsules (HCs) with macromole..
Bio-Click Chemistry: Enzymatic Functionalization of PEGylated Capsules for Targeting Applications
Melissa KM Leung, Christoph E Hagemeyer, Angus PR Johnston, Catalina Gonzales, Marloes MJ Kamphuis, Katie Ardipradja, Georgina K Such, Karlheinz Peter, Frank Caruso
All sorted: The enzyme Sortase A was used to catalyze functionalization of PEGylated capsules with an activation-specific anti-pla..
Cellular Association and Cargo Release of Redox-Responsive Polymer Capsules Mediated by Exofacial Thiols
Yan Yan, Yajun Wang, Joan K Heath, Edouard C Nice, Frank Caruso
Redox-responsive polymer capsules stabilized by disulfide bonds and loaded with hydrophobic cargo are prepared by templating mesop..
Polymersome-Loaded Capsules for Controlled Release of DNA
Hannah Lomas, Angus PR Johnston, Georgina K Such, Zhiyuan Zhu, Kang Liang, Martin P van Koeverden, Siripong Alongkornchotikul, Frank Caruso
The formation of a novel drug-delivery carrier for the controlled release of plasmid DNA that comprises layer-by-layer polymer cap..
Bypassing Multidrug Resistance in Cancer Cells with Biodegradable Polymer Capsules
Yan Yan, Christopher J Ochs, Georgina K Such, Joan K Heath, Edouard C Nice, Frank Caruso
Biodegradable polymer capsules with drug-loaded multilayers were prepared through click chemistry via layer-by-layer assembly. The..
Targeting of Cancer Cells Using Click-Functionalized Polymer Capsules
Marloes MJ Kamphuis, Angus PR Johnston, Georgina K Such, Henk H Dam, Richard A Evans, Andrew M Scott, Edouard C Nice, Joan K Heath, Frank Caruso
Targeted delivery of drugs to specific cells allows a high therapeutic dose to be delivered to the target site with minimal harmfu..
Encapsulation of Water-Insoluble Drugs in Polymer Capsules Prepared Using Mesoporous Silica Templates for Intracellular Drug Delivery
Yajun Wang, Yan Yan, Jiwei Cui, Leticia Hosta-Rigau, Joan K Heath, Edouard C Nice, Frank Caruso
Water-insoluble compounds were encapsulated in polymer capsules through mesoporous silica nanoparticle-mediated layer-by-layer ass..
Uptake and Intracellular Fate of Disulfide-Bonded Polymer Hydrogel Capsules for Doxorubicin Delivery to Colorectal Cancer Cells
Yan Yan, Angus PR Johnston, Sarah J Dodds, Marloes MJ Kamphuis, Charles Ferguson, Robert G Parton, Edouard C Nice, Joan K Heath, Frank Caruso
Understanding the interactions between drug carriers and cells is of importance to enhance the delivery of therapeutics. The relea..