Australian Genomewide Association Study in Osteoporosis

Grant number: 511132 | Funding period: 2009 - 2010

Completed

Abstract

Osteoporosis is a common condition in which bone strength is reduced due to reduced amount and quality of bone. Reduced bone strength means an increased risk of fracture. Osteoporotic fractures occur in 1 in 2 women and 1 in 3 men in their lifetime, and the likelihood of suffering osteoporotic fracture increases with age. Most of the risk of developing osteoporosis is genetic, but few of the genes involved have been identified. Our goal is to identify those genes.

Related publications (2)

The genetic associations of acute anterior uveitis and their overlap with the genetics of ankylosing spondylitis

PC Robinson, PJ Leo, JJ Pointon, J Harris, K Cremin, LA Bradbury, P Donnelly, I Barroso, JM Blackwell, E Bramon, MA Brown, JP Casas, A Corvin, P Deloukas, A Duncanson, J Jankowski, HS Markus, CG Mathew, CNA Palmer, R Plomin

2016-01-01

Genome-wide association study using extreme truncate selection identifies novel genes affecting bone mineral density and fracture risk

EL Duncan, P Danoy, JP Kemp, PJ Leo, E McCloskey, GC Nicholson, R Eastell, RL Prince, JA Eisman, G Jones, PN Sambrook, IR Reid, EM Dennison, J Wark, JB Richards, AG Uitterlinden, TD Spector, C Esapa, RD Cox, SDM Brown

2011-04-01

Osteoporotic fracture is a major cause of morbidity and mortality worldwide. Low bone mineral density (BMD) is a major predisposin..

University of Melbourne Researchers

Ego Seeman

John Wark