PREVENTION AND TREATMENT OF CHRONIC HEART AND KIDNEY DISEASE VIA EPIDEMIOLOGICAL, PHARMACOLOGICAL DEVICE AND CELL-BASED APPROACHES
Grant number: 546272 | Funding period: 2010 - 2014
Heart failure describes where the heart cannot pump adequately to meet the needs of the body. This condition has a high mortality despite recent advances in therapy, therefore, there is an urgent need for new approaches to this condition. The present grant aims to: (1) identify patients at high-risk for future development of this condition where early intervention with drugs may reduce or prevent the development of new heart failure; (2) use novel drugs, devices and stem cell therapies to identify ways to better treat patients with existing disease; (3) focus on the effect of heart failure on the kidney and vice versa via early diagnosis and treatment strategies
Related publications (29)
Association of depression with mortality in an elderly treated hypertensive population
Enayet K Chowdhury, Michael Berk, Mark R Nelson, Lindon MH Wing, Christopher M Reid
UNLABELLED: ABSTRACTBackground:Both elevated blood pressure and/or depression increase the risk of cardiovascular disease and mort..
Inhibition of Apoptosis Signal-Regulating Kinase 1 Attenuates Myocyte Hypertrophy and Fibroblast Collagen Synthesis
Wendi Yang, Bing Hui Wang, Ian Wang, Li Huang, Feby Savira, Andrew Kompa, Beat M Jucker, Robert N Willette, Darren Kelly, Henry Krum, Zhiliang Li, Qian Fu
BACKGROUND: Cardiac remodelling is a dynamic process whereby structural and functional changes occur within the heart in response ..
Short- and long-term association of lipid-lowering drug treatment and cardiovascular disease by estimated absolute risk in the Second Australian National Blood Pressure study
Chau LB Ho, Enayet K Chowdhury, Monique Breslin, Jenny Doust, Christopher M Reid, Lindon MH Wing, Mark R Nelson, Lawrence J Beilin, Garry L Jennings, Collin I Johnston, Graham J Macdonald, John E Marley, John J McNeil, Trefor O Morgan, Christopher M Reid, Philip Ryan, Malcolm J West, Lindon MH Wing
BACKGROUND: There is currently insufficient evidence to support the use of lipid-lowering drug treatment (LLT) for primary prevent..
Relation of Alcohol Consumption to Risk of Heart Failure in Patients Aged 65 to 84 Years With Hypertension
Berhe W Sahle, Alice J Owen, Lindon MH Wing, Lawrence J Beilin, Mark R Nelson, Garry LR Jennings, Christopher M Reid
Although a high level of alcohol consumption is associated with cardiomyopathy, the benefit or risk of moderate alcohol consumptio..
Angiotensin receptor neprilysin inhibition provides superior cardioprotection compared to angiotensin converting enzyme inhibition after experimental myocardial infarction
Andrew R Kompa, Jiayu Lu, Thomas J Weller, Darren J Kelly, Henry Krum, Thomas G von Lueder, Bing H Wang
BACKGROUND: Angiotensin receptor neprilysin inhibitor (ARNi) enhances beneficial natriuretic peptides by inhibiting their breakdow..
Chronic kidney disease with comorbid cardiac dysfunction exacerbates cardiac and renal damage
Shan Liu, Bing H Wang, Darren J Kelly, Henry Krum, Andrew R Kompa
To address the pathophysiological mechanisms underlying chronic kidney disease with comorbid cardiac dysfunction, we investigated ..
Long-term survival following the development of heart failure in an elderly hypertensive population
Berhe W Sahle, Alice J Owen, Lindon MH Wing, Lawrence J Beilin, Henry Krum, Christopher M Reid
BACKGROUND: Available data on the prognosis of heart failure (HF) patients are predominantly limited to patients diagnosed at time..
Prediction of 10-year Risk of Incident Heart Failure in Elderly Hypertensive Population: The ANBP2 Study
Berhe W Sahle, Alice J Owen, Lindon MH Wing, Mark R Nelson, Garry LR Jennings, Christopher M Reid
BACKGROUND: Multivariable risk prediction models consisting of routinely collected measurements can facilitate early detection and..
Incidence of heart failure in 6083 elderly hypertensive patients: the Second Australian National Blood Pressure Study (ANBP2)
Berhe W Sahle, Alice J Owen, Henry Krum, Christopher M Reid
AIMS: Hypertension is a known risk factor for the development of heart failure (HF); however, few data are available on the magnit..
TRAF2 regulates TNF and NF-kappa B signalling to suppress apoptosis and skin inflammation independently of Sphingosine kinase 1
Nima Etemadi, Michael Chopin, Holly Anderton, Maria C Tanzer, James A Rickard, Waruni Abeysekera, Cathrine Hall, Sukhdeep K Spall, Bing Wang, Yuquan Xiong, Timothy Hla, Stuart M Pitson, Claudine S Bonder, Wendy Wei-Lynn Wong, Matthias Ernst, Gordon K Smyth, David L Vaux, Stephen L Nutt, Ueli Nachbur, John Silke
TRAF2 is a component of TNF superfamily signalling complexes and plays an essential role in the regulation and homeostasis of immu..
Rate of Change in Renal Function and Mortality in Elderly Treated Hypertensive Patients
Enayet K Chowdhury, Robyn G Langham, Zanfina Ademi, Alice Owen, Henry Krum, Lindon MH Wing, Mark R Nelson, Christopher M Reid
BACKGROUND AND OBJECTIVES: Evidence relating the rate of change in renal function, measured as eGFR, after antihypertensive treatm..
Contribution of microRNA to pathological fibrosis in cardiorenal syndrome: impact of uremic toxins
Indrajeetsinh Rana, Andrew R Kompa, Joanna Skommer, Bing H Wang, Suree Lekawanvijit, Darren J Kelly, Henry Krum, Fadi J Charchar
Progressive reduction in kidney function in patients following myocardial infarction (MI) is associated with an increase in circul..
Comparison of Predictive Performance of Renal Function Estimation Equations for All-Cause and Cardiovascular Mortality in an Elderly Hypertensive Population
Enayet K Chowdhury, Robyn G Langham, Alice Owen, Henry Krum, Lindon MH Wing, Mark R Nelson, Christopher M Reid
BACKGROUND: The Modifications of Diet in Renal Disease (MDRD) and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) are ..
Angiotensin Receptor Neprilysin Inhibitor LCZ696 Attenuates Cardiac Remodeling and Dysfunction After Myocardial Infarction by Reducing Cardiac Fibrosis and Hypertrophy
Thomas G von Lueder, Bing H Wang, Andrew R Kompa, Li Huang, Randy Webb, Pierre Jordaan, Dan Atar, Henry Krum
BACKGROUND: Angiotensin receptor neprilysin inhibitors (ARNi), beyond blocking angiotensin II signaling, augment natriuretic pepti..
Predictors of health care use among patients with or at high risk of atherothrombotic disease: Two-year follow-up data
Zanfina Ademi, Danny Liew, Alexandra Gorelik, Megan Bohensky, Ella Zomer, Bruce Hollingsworth, Gabriel Steg, Deepak L Bhatt, Christopher M Reid
BACKGROUND: Atherothrombotic diseases are the leading health problems in the world, both in terms of morbidity and mortality. This..
Predictors of Mean Arterial Pressure Morning Rate of Rise and Power Function in Subjects Undergoing Ambulatory Blood Pressure Recording
Geoffrey A Head, Nick Andrianopoulos, Barry P McGrath, Catherine A Martin, Melinda J Carrington, Elena V Lukoshkova, Pamela J Davern, Garry L Jennings, Christopher M Reid
BACKGROUND: We determined clinical predictors of the rate of rise (RoR) in blood pressure in the morning as well as a novel measur..
The Asia-Pacific Evaluation of Cardiovascular Therapies (ASPECT) Collaboration -Improving the quality of cardiovascular care in the Asia Pacific Region
Christopher M Reid, Bryan Yan, Wan Azman Wan Ahmad, Liew Houng Bang, Sim Kui Hian, Terrance Chua, Mark Chan, John Beltrame, Stephen J Duffy, Angela Brennan, Andrew Ajani
BACKGROUND: Clinicians and other stakeholders recognize the need for clinical registries to monitor data in order to improve the o..
The Uremic Toxin Adsorbent AST-120 Abrogates Cardiorenal Injury Following Myocardial Infarction
Suree Lekawanvijit, Sirinart Kumfu, Bing H Wang, Minako Manabe, Fuyuhiko Nishijima, Darren J Kelly, Henry Krum, Andrew R Kompa
An accelerated progressive decline in renal function is a frequent accompaniment of myocardial infarction (MI). Indoxyl sulfate (I..
Subtotal nephrectomy accelerates pathological cardiac remodeling post-myocardial infarction: Implications for cardiorenal syndrome
Shan Liu, Andrew R Kompa, Sirinart Kumfu, Fuyuhiko Nishijima, Darren J Kelly, Henry Krum, Bing H Wang
BACKGROUND: To further understand the pathophysiology of concomitant cardiac and renal dysfunction, we investigated molecular, str..
A new anti-fibrotic drug attenuates cardiac remodeling and systolic dysfunction following experimental myocardial infarction
Yuan Zhang, Maros Elsik, Amanda J Edgley, Alison J Cox, Andrew R Kompa, Bing Wang, Christina Yan Ru Tan, Fay L Khong, David I Stapleton, Steven Zammit, Spencer J Williams, Richard E Gilbert, Henry Krum, Darren J Kelly
BACKGROUND: Pathological deposition of extracellular matrix in the non-infarct zone (NIZ) of the ventricle post myocardial infarct..
Soluble epoxide hydrolase inhibition exerts beneficial anti-remodeling actions post-myocardial infarction
Andrew R Kompa, Bing H Wang, Guoying Xu, Yuan Zhang, Pei-Yu Ho, Stephen Eisennagel, Reema K Thalji, Joseph P Marino, Darren J Kelly, David J Behm, Henry Krum
BACKGROUND: A contributory role for soluble epoxide hydrolase (sEH) in cardiac remodeling post-myocardial infarction (MI) has been..
Myosin Heads Are Displaced from Actin Filaments in the In Situ Beating Rat Heart in Early Diabetes
Mathew J Jenkins, James T Pearson, Daryl O Schwenke, Amanda J Edgley, Takashi Sonobe, Yutaka Fujii, Hatsue Ishibashi-Ueda, Darren J Kelly, Naoto Yagi, Mikiyasu Shirai
Diabetes is independently associated with a specific cardiomyopathy, characterized by impaired cardiac muscle relaxation and force..
Attenuation of Armanni-Ebstein lesions in a rat model of diabetes by a new anti-fibrotic, anti-inflammatory agent, FT011
X Lau, Y Zhang, DJ Kelly, DI Stapleton
AIMS/HYPOTHESIS: A key morphological feature of diabetic nephropathy is the accumulation and deposition of glycogen in renal tubul..
A Purpose-Synthesised Anti-Fibrotic Agent Attenuates Experimental Kidney Diseases in the Rat
Richard E Gilbert, Yuan Zhang, Spencer J Williams, Steven C Zammit, David I Stapleton, Alison J Cox, Henry Krum, Robyn Langham, Darren J Kelly
BACKGROUND AND PURPOSE: Locally-active growth factors have been implicated in the pathogenesis of many diseases in which organ fib..
Chronic Kidney Disease-Induced Cardiac Fibrosis Is Ameliorated by Reducing Circulating Levels of a Non-Dialysable Uremic Toxin, Indoxyl Sulfate
Suree Lekawanvijit, Andrew R Kompa, Minako Manabe, Bing H Wang, Robyn G Langham, Fuyuhiko Nishijima, Darren J Kelly, Henry Krum
Cardiovascular death commonly occurs in patients with chronic kidney disease. Indoxyl sulfate (IS), a uremic toxin, has been demon..
FT011, a new anti-fibrotic drug, attenuates fibrosis and chronic heart failure in experimental diabetic cardiomyopathy
Yuan Zhang, Amanda J Edgley, Alison J Cox, Andrew K Powell, Bing Wang, Andrew R Kompa, David I Stapleton, Steven C Zammit, Spencer J Williams, Henry Krum, Richard E Gilbert, Darren J Kelly
AIMS: Cardiac remodelling in diabetes includes pathological accumulation of extracellular matrix and myocyte hypertrophy that cont..