EPIGENETIC CONTROL OF ANTIGENETIC VARIATION IN PLASMODIUM FALCIPARUM

Grant number: 461231 | Funding period: 2009 - 2009

Completed

Abstract

Malaria is an enormous global health problem that kills millions of people each year. Humans develop only partial immunity to malaria only if they survive many years of repeated infection. Much of the difficulty in developing immunity to malaria lies in the ability of the causative agent, Plasmodium falciparum, to continually change the properties of its surface coat. The parasite achieves this immune evasion through a process called antigenic variation. Genetically identical parasites can express different surface coats, and the control of this process is superimposed above the level of genetic control. This system is referred to as epigenetic control. Epigenetic control includes regulatory..

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