Characterisation of Cumulus Cell Molecular Mediators of Oocyte Health

Grant number: 1008137 | Funding period: 2011 - 2013

Completed

Abstract

Many women are poorly fertile because of poor egg quality due to age, disease and lifestyle. IVF can assist, but requires large doses of hormone, which can lead to significant health risks. IVM is an alternative lab technique to IVF, but has very poor success. We discovered that synthetic proteins copied from recently discovered egg proteins can be added to the egg and substantially increase IVM success. Answering why will further will aid treatment for infertile women

Related publications (2)

Redox and anti-oxidant state within cattle oocytes following in vitro maturation with bone morphogenetic protein 15 and follicle stimulating hormone

ML Sutton-Mcdowall, M Purdey, HM Brown, AD Abell, DG Mottershead, PD Cetica, GC Dalvit, EM Goldys, RB Gilchrist, DK Gardner, JG Thompson

2015-04-01

The developmental competence of cumulus oocyte complexes (COCs) can be increased during in vitro oocyte maturation with the additi..

Metabolic differences in bovine cumulus-oocyte complexes matured in vitro in the presence or absence of follicle-stimulating hormone and bone morphogenetic protein 15

ML Sutton-Mcdowall, DG Mottershead, DK Gardner, RB Gilchrist, JG Thompson

2012-10-01

Bidirectional communication between cumulus cells and the oocyte is necessary to achieve oocyte developmental competence.The aim o..

University of Melbourne Researchers

David Gardner