FUNCTIONAL STUDIES ON THE ROLE OF DNP73 IN STEM CELLS AND CANCER
Grant number: 1010429 | Funding period: 2011 - 2013
This project investigates the role of the p73 gene in regulating stem cells and facilitating intestinal cancer formation. We hypothesize that when a particular form of this gene (DNp73) is upregulated it prevents differentiation of stem cells and promotes tumour formation. We combine novel approaches in mice and fruit flies to examine the function of DNp73 in stem cells with analysis of human tumour samples. These studies may identify a new target for tumour therapy.