PET IMAGING AGENTS FOR THE DIFFERENTIAL DIAGNOSIS OF HYPOXIC TUMORS
Grant number: 1011418 | Funding period: 2011 - 2016
Choosing the best type of treatment from the ever increasing arsenal of chemotherapeutic agents against cancer is of critical importance. Tumor hypoxia requires specialized treatment and patient selection. Current PET imaging agents cannot differentiate between severely and mildly hypoxic tumors. We have found a new agent that can detect mildly hypoxic tumors and the aim of this grant application is to further develop this radiotracer to improve image quality and reliability of the diagnosis.
Related publications (3)
Toward Hypoxia-Selective Rhenium and Technetium Tricarbonyl Complexes
Andrea J North, David J Hayne, Christine Schieber, Katherine Price, Anthony R White, Peter J Crouch, Angela Rigopoulos, Graeme J O'Keefe, Henri Tochon-Danguy, Andrew M Scott, Jonathan M White, Uwe Ackermann, Paul S Donnelly
Synthesis of 2-[(4-[18F]Fluorobenzoyloxy)methyl]-1,4-naphthalenedione from 2-hydroxymethyl 1,4-naphthoquinone and 4-[18F]fluorobenzoic acid using dicyclohexyl carbodiimide
Uwe Ackermann, Duanne Sigmund, Shinn Dee Yeoh, Angela Rigopoulos, Graeme O'Keefe, Glenn Cartwright, Jonathan White, Andrew M Scott, Henri J Tochon-Danguy