Investigating the Mechanisms of Regulation of Mycobacterial Cell Wall Biosynthesis

Abstract

Tuberculosis (TB) kills around two million people each year while the causative bacterial species, Mycobacterium tuberculosis, infects one-third of the entire human population. An alarmingly high rate of TB exists in Australia's indigenous population. This proposal aims to identify and characterise essential processes involved in synthesis of the outer coat of the bacterium which are potential targets for new drugs for the treatment of this devastating disease.

Related publications (1)

Acetylation of trehalose mycolates is required for efficient MmpL-mediated membrane transport in corynebacterineae

Y Yamaryo-Botte, AK Rainczuk, DJ Lea-Smith, R Brammananth, PL Van Der Peet, P Meikle, JE Ralton, TWT Rupasinghe, SJ Williams, RL Coppel, PK Crellin, MJ McConville

2015-03-20

Pathogenic species of Mycobacteria and Corynebacteria, including Mycobacterium tuberculosis and Corynebacterium diphtheriae, synth..