Importance of the Brain Renin-Angiotensin System for Regulating Blood Pressure and Cardiovascular Autonomic Function

Grant number: 1007451 | Funding period: 2011 - 2013

Completed

Abstract

The peptide angiotensin a major regulator of many brain areas controlling blood volume and blood pressure. Brain angiotensin may well contribute to high blood pressure but how it acts in each of the different brain areas is unknown. New gene transfer technology using viruses combined with genetically modified mice will enable this project to inactivate or activate angiotensin in each brain nucleus and determine the role of individual areas to setting of blood pressure leading to hypertension.

Related publications (6)

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Viscerosensory input drives angiotensin II type 1A receptor-expressing neurons in the solitary tract nucleus

DA Carter, H Guo, AA Connelly, JK Bassi, AY Fong, AM Allen, SJ McDougall

2018-02-01

Homeostatic regulation of visceral organ function requires integrated processing of neural and neurohormonal sensory signals. The ..

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Functional and neurochemical characterization of angiotensin type 1A receptor-expressing neurons in the nucleus of the solitary tract of the mouse

DA Carter, YT Choong, AA Connelly, JK Bassi, NO Hunter, N Thongsepee, IJ Llewellyn-Smith, AY Fong, SJ McDougall, AM Allen

2017-10-09

Angiotensin II acts via two main receptors within the central nervous system, with the type 1A receptor (AT<inf>1A</inf>R) most wi..

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Angiotensin type 1A receptor expression in C1 neurons of the rostral ventrolateral medulla contributes to the development of angiotensin-dependent hypertension

N Jancovski, DA Carter, AA Connelly, E Stevens, JK Bassi, C Menuet, AM Allen

2014-12-01

New Findings: What is the central question of this study? This study addresses the mechanism by which deletion of angiotensin II t..

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Baroreceptor reflex control of heart rate in angiotensin type 1A receptor knockout mice

YT Choong, C Menuet, N Jancovski, AM Allen

2013-11-01

The baroreceptor reflex dampens the short-term fluctuations in blood pressure by feedback modulation of heart rate (HR) and vascul..

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Stimulation of angiotensin type 1A receptors on catecholaminergic cells contributes to angiotensin-dependent hypertension

N Jancovski, JK Bassi, DA Carter, YT Choong, A Connelly, TP Nguyen, D Chen, EV Lukoshkova, C Menuet, GA Head, AM Allen

2013-11-01

Hypertension contributes to multiple forms of cardiovascular disease and thus morbidity and mortality. The mechanisms inducing hyp..

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Angiotensin type 1A receptors in C1 neurons of the rostral ventrolateral medulla modulate the pressor response to aversive stress

D Chen, N Jancovski, JK Bassi, TP Nguyen-Huu, YT Choong, K Palma-Rigo, PJ Davern, SB Gurley, WG Thomas, GA Head, AM Allen

2012-02-08

The rise in blood pressure during an acute aversive stress has been suggested to involve activation of angiotensin type 1A recepto..

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