Rotavirus infection of type 1 interferon receptor knockout NOD mice

Abstract

Rotavirus infection is the main cause of severe diarrhoea in children, and has been implicated in accelerated progression of genetically at-risk children towards type 1 diabetes in two independent studies. My group has further discovered that rotavirus also accelerates diabetes onset in mice in a novel immunological process. In this project, we will determine the mechanism behind this disease exacerbation in the mice, to facilitate understanding of the process in children.

Related publications (1)

Rotavirus Activates Lymphocytes from Non-Obese Diabetic Mice by Triggering Toll-Like Receptor 7 Signaling and Interferon Production in Plasmacytoid Dendritic Cells

Jessica A Pane, Nicole L Webster, Barbara S Coulson

2014-03-01

It has been proposed that rotavirus infection promotes the progression of genetically-predisposed children to type 1 diabetes, a c..