Generating Virus Resistant Immune Cells

Endogenous murine BST-2/tetherin is not a major restriction factor of influenza a virus infection

SL Londrigan, MD Tate, ER Job, JM Moffat, LM Wakim, CA Gonelli, DFJ Purcell, AG Brooks, JA Villadangos, PC Reading, JD Mintern

2015-11-01

BST-2 (tetherin, CD317, HM1.24) restricts virus growth by tethering enveloped viruses to the cell surface. The role of BST-2 durin..

Respiratory DC use IFITM3 to avoid direct viral infection and safeguard virus-specific CD8 T cell priming

G Infusini, JM Smith, H Yuan, A Pizzolla, WC Ng, SL Londrigan, A Haque, PC Reading, JA Villadangos, LM Wakim

2015-11-01

Respiratory dendritic cells (DC) play a pivotal role in the initiation of adaptive immune responses to influenza virus. To do this..

Antibody-targeted vaccination to lung dendritic cells generates tissue-resident memory CD8 T cells that are highly protective against influenza virus infection

LM Wakim, J Smith, I Caminschi, MH Lahoud, JA Villadangos

2015-09-19

Influenza virus gains entry into the body by inhalation and initiates its replication cycle within the lung. The early stage of in..