ARC CENTRE OF EXCELLENCE FOR ELECTROMATERIALS SCIENCE

Electro-compacted collagen for corneal epithelial tissue engineering.

Zhi Chen, Xiao Liu, Jingjing You, Eva Tomaskovic-Crook, Zhilian Yue, Alireza Talaei, Gerard Sutton, Jeremy Crook, Gordon Wallace

2023-01-18

Bioengineered corneal substitutes offer a solution to the shortage of donor corneal tissue worldwide. As one of the major structur..

The impact of electrical stimulation protocols on neuronal cell survival and proliferation using cell-laden GelMA/graphene oxide hydrogels

Alexandre Xavier Mendes, Adriana Teixeira do Nascimento, Serena Duchi, Anita F Quigley, Lilith Caballero M Aguilar, Chaitali Dekiwadia, Robert MI Kapsa, Saimon Moraes Silva, Simon E Moulton

2022-12-19

The development of electroactive cell-laden hydrogels (bioscaffolds) has gained interest in neural tissue engineering research due..

Durable Electrooxidation of Acidic Water Catalysed by a Cobalt-Bismuth-based Oxide Composite: An Unexpected Role of the F-doped SnO2 Substrate

Hoang-Long Du, Manjunath Chatti, Brittany Kerr, Cuong K Nguyen, Thanh Tran-Phu, Dijon A Hoogeveen, Pavel V Cherepanov, Anthony SR Chesman, Bernt Johannessen, Antonio Tricoli, Rosalie K Hocking, Douglas R MacFarlane, Alexandr N Simonov

2022-04-26

Aiming to design a catalyst for stable electrooxidation of water at low pH, the present work explores the properties and structura..

Induced Pluripotent Stem Cell-Based Systems for Personalising Epilepsy Treatment: Research Ethics Challenges and New Insights for the Ethics of Personalised Medicine.

Mary Jean Walker, Jane Nielsen, Eliza Goddard, Alex Harris, Katrina Hutchison

2022-04-01

ABSTRACTThis paper examines potential ethical and legal issues arising during the research, development and clinical use of a prop..

Induced pluripotent stem cells for 2D and 3D modelling the biological basis of schizophrenia and screening possible therapeutics

Eva Tomaskovic-Crook, Kyle Guerrieri-Cortesi, Jeremy Micah Crook

2021-07-20

Induced pluripotent stem cells (iPSCs) are providing unprecedented insight into complex neuropsychiatric disorders such as schizop..

Nitrogen reduction to ammonia at high efficiency and rates based on a phosphonium proton shuttle.

Bryan HR Suryanto, Karolina Matuszek, Jaecheol Choi, Rebecca Y Hodgetts, Hoang-Long Du, Jacinta M Bakker, Colin SM Kang, Pavel V Cherepanov, Alexandr N Simonov, Douglas R MacFarlane

2021-06-11

Ammonia (NH3) is a globally important commodity for fertilizer production, but its synthesis by the Haber-Bosch process causes sub..

Dielectric Elastomer Actuators, Neuromuscular Interfaces, and Foreign Body Response in Artificial Neuromuscular Prostheses: A Review of the Literature for an In Vivo Application

Alessandro Bruschi, Davide Maria Donati, Peter Choong, Enrico Lucarelli, Gordon Wallace

2021-06-04

The inability to replace human muscle in surgical practice is a significant challenge. An artificial muscle controlled by the nerv..

Engineering in vitro human neural tissue analogs by 3D bioprinting and electrostimulation

Danielle Warren, Eva Tomaskovic-Crook, Gordon G Wallace, Jeremy M Crook

2021-06-01

There is a fundamental need for clinically relevant, reproducible, and standardized in vitro human neural tissue models, not least..

Enhanced Electroactivity, Mechanical Properties, and Printability through the Addition of Graphene Oxide to Photo-Cross-linkable Gelatin Methacryloyl Hydrogel

Alexandre Xavier Mendes, Saimon Moraes Silva, Cathal D O'Connell, Serena Duchi, Anita F Quigley, Robert M Kapsa, Simon E Moulton

2021-05-06

The human tissues most sensitive to electrical activity such as neural and muscle tissues are relatively soft, and yet traditional..

Potentially Wearable Thermo-Electrochemical Cells for Body Heat Harvesting: From Mechanism, Materials, Strategies to Applications

Yuqing Liu, Hongbo Wang, Peter C Sherrell, Lili Liu, Yong Wang, Jun Chen

2021-04-29

Wearable electronics are becoming one of the key technologies in health care applications including health monitoring, data acquis..

Understanding charge transfer on the clinically used conical Utah electrode array: charge storage capacity, electrochemical impedance spectroscopy and effective electrode area

Alexander R Harris

2021-04-01

Objective. The Utah electrode is used for pre/clinical studies on neural recording and stimulation. Anecdotal and empirical report..

Bioengineering Clinically Relevant Cardiomyocytes and Cardiac Tissues from Pluripotent Stem Cells

Emma Claire James, Eva Tomaskovic-Crook, Jeremy Micah Crook

2021-03-01

The regenerative capacity of cardiomyocytes is insufficient to functionally recover damaged tissue, and as such, ischaemic heart d..

Fibrinogen, collagen, and transferrin adsorption to poly(3,4-ethylenedioxythiophene)-xylorhamno-uronic glycan composite conducting polymer biomaterials for wound healing applications

Paul J Molino, John Will, Luciana Yumiko Daikuara, Alexander R Harris, Zhilian Yue, Jeremy Dinoro, Pia Winberg, Gordon G Wallace

2021-03-01

We present the conducting polymer poly (3,4-ethylenedioxythiophene) (PEDOT) doped with an algal-derived glycan extract, Phycotrix™..

Impact of Protein Fouling on the Charge Injection Capacity, Impedance, and Effective Electrode Area of Platinum Electrodes for Bionic Devices

Alexander R Harris, Paul Carter, Robert Cowan, Gordon G Wallace

2021-02-15

The impact of protein fouling on platinum electrodes was assessed by electrochemical methods. Protein fouling affected the electro..

A 3D printed graphene electrode device for enhanced and scalable stem cell culture, osteoinduction and tissue building

Jianfeng Li, Xiao Liu, Jeremy M Crook, Gordon G Wallace

2021-01-21

Bone related diseases and disorders increasingly impact human health. Electrical stimulation (ES) has been shown to promote osteog..

Electrostatically Tuning the Photodissociation of the Irgacure 2959 Photoinitiator in the Gas Phase by Cation Binding

Samuel JP Marlton, Benjamin McKinnon, Nicholas S Hill, Michelle L Coote, Adam J Trevitt

2021-01-11

The low-lying electronic states of Irgacure 2959, a Norrish-type I photoinitiator, complexed with a single metal cation are invest..

Biomimetic corneal stroma using electro-compacted collagen

Zhi Chen, Xiao Liu, Jingjing You, Yihui Song, Eva Tomaskovic-Crook, Gerard Sutton, Jeremy M Crook, Gordon G Wallace

2020-09-01

Engineering substantia propria (or stroma of cornea) that mimics the function and anatomy of natural tissue is vital for in vitro ..

3D Printing of Cytocompatible Graphene/Alginate Scaffolds for Mimetic Tissue Constructs

Jianfeng Li, Xiao Liu, Jeremy M Crook, Gordon G Wallace

2020-07-17

Tissue engineering, based on a combination of 3D printing, biomaterials blending and stem cell technology, offers the potential to..

Fe/Co-based Bimetallic MOF-derived Co3Fe7@NCNTFs Bifunctional Electrocatalyst for High-Efficiency Overall Water Splitting

Qunyao Yuan, Youxing Yu, Peter C Sherrell, Jun Chen, Xiaofang Bi

2020-04-29

Electrocatalytic water splitting to produce hydrogen and oxygen is regarded as one of the most promising methods to generate clean..

Conducting Polymer Mediated Electrical Stimulation Induces Multilineage Differentiation with Robust Neuronal Fate Determination of Human Induced Pluripotent Stem Cells

Eva Tomaskovic-Crook, Qi Gu, Siti N Abdul Rahim, Gordon G Wallace, Jeremy M Crook

2020-03-01

Electrical stimulation is increasingly being used to modulate human cell behaviour for biotechnological research and therapeutics...

Wet-Spun Trojan Horse Cell Constructs for Engineering Muscle

Anita F Quigley, Rhys Cornock, Tharun Mysore, Javad Foroughi, Magdalena Kita, Joselito M Razal, Jeremy Crook, Simon E Moulton, Gordon G Wallace, Robert MI Kapsa

2020-02-20

Engineering of 3D regenerative skeletal muscle tissue constructs (skMTCs) using hydrogels containing muscle precursor cells (MPCs)..

Tuning drug dosing through matching optically active polymer composition and NIR stimulation parameters

Shaun W Gietman, Saimon M Silva, Blanca del Rosal, Robert MI Kapsa, Paul R Stoddart, Simon E Moulton

2020-02-15

Controlled release is at the forefront of modern bioscience as it aims to address challenges associated with the dosing of drugs w..

Electrical stimulation-induced osteogenesis of human adipose derived stem cells using a conductive graphene-cellulose scaffold

Jianfeng Li, Xiao Liu, Jeremy M Crook, Gordon G Wallace

2020-02-01

The versatile properties of graphene-based materials are enabling various tissue regeneration, towards meeting an ever increasing ..

3D Bioprinting and Differentiation of Primary Skeletal Muscle Progenitor Cells

Catherine Ngan, Anita Quigley, Cathal O'Connell, Magdalena Kita, Justin Bourke, Gordon G Wallace, Peter Choong, Robert MI Kapsa

2020-01-01

Volumetric loss of skeletal muscle can occur through sports injuries, surgical ablation, trauma, motor or industrial accident, and..

3D Bioprinting Electrically Conductive Bioink with Human Neural Stem Cells for Human Neural Tissues

Eva Tomaskovic-Crook, Jeremy M Crook

2020-01-01

Bioprinting cells with an electrically conductive bioink provides an opportunity to produce three-dimensional (3D) cell-laden cons..

Bioprinting 3D Human Induced Pluripotent Stem Cell Constructs for Multilineage Tissue Engineering and Modeling

Jeremy M Crook, Eva Tomaskovic-Crook

2020-01-01

Bioprinting human pluripotent stem cells (PSCs) provides an opportunity to produce three-dimensional (3D) cell-laden constructs wi..

Cell Processing for 3D Bioprinting: Quality Requirements for Quality Assurance in Fundamental Research and Translation

Jeremy M Crook

2020-01-01

Bioprinting is an additive manufacturing process where biomaterials-based inks are printed layer-by-layer to create three-dimensio..

3D graphene-containing structures for tissue engineering

J Li, X Liu, JM Crook, GG Wallace

2019-12-01

Graphene and its derivatives have been extensively explored in various fields and have shown great promise toward energy harvestin..

Electrochemical methods for analysing and controlling charge transfer at the electrode-tissue interface

Alexander R Harris, Gordon G Wallace

2019-08-01

There have been rapid advances in the development of new materials for use in electrode–tissue interfacing. The development of con..

Human Neural Tissues from Neural Stem Cells Using Conductive Biogel and Printed Polymer Microelectrode Arrays for 3D Electrical Stimulation

Eva Tomaskovic-Crook, Peikai Zhang, Annika Ahtiainen, Heidi Kaisvuo, Chong-Yong Lee, Stephen Beirne, Zaid Aqrawe, Darren Svirskis, Jari Hyttinen, Gordon G Wallace, Jadranka Travas-Sejdic, Jeremy M Crook

2019-08-01

Electricity is important in the physiology and development of human tissues such as embryonic and fetal development, and tissue re..

Insights into the Electron Transfer Kinetics, Capacitance and Resistance Effects of Implantable Electrodes Using Fourier Transform AC Voltammetry on Platinum

Alexander R Harris, Carrie Newbold, Robert Cowan, Gordon G Wallace

2019-07-03

The charge transfer mechanism at the electrode-solution interface was assessed by Fourier transform AC voltammetry (FTACV). The fa..

Predicting neural recording performance of implantable electrodes

Alexander R Harris, Ben J Allitt, Antonio G Paolini

2019-05-07

Recordings of neural activity can be used to aid communication, control prosthetic devices or alleviate disease symptoms. Chronic ..

Fabrication of a Biocompatible Liquid Crystal Graphene Oxide-Gold Nanorods Electro- and Photoactive Interface for Cell Stimulation

Daniela Duc, Paul R Stoddart, Sally L McArthur, Robert M Kapsa, Anita F Quigley, Mitchell Boyd-Moss, Simon E Moulton

2019-05-01

For decades, electrode-tissue interfaces are pursued to establish electrical stimulation as a reliable means to control neuronal c..

Using Chronopotentiometry to Better Characterize the Charge Injection Mechanisms of Platinum Electrodes Used in Bionic Devices

Alexander R Harris, Carrie Newbold, Paul Carter, Robert Cowan, Gordon G Wallace

2019-04-24

The safe charge injection capacity and charge density of neural stimulating electrodes is based on empirical evidence obtained fro..

Smart graphene-cellulose paper for 2D or 3D "origami-inspired" human stem cell support and differentiation

Jianfeng Li, Xiao Liu, Eva Tomaskovic-Crook, Jeremy M Crook, Gordon G Wallace

2019-04-01

Graphene-based materials represent advanced platforms for tissue engineering and implantable medical devices. From a clinical stan..

Room temperature CO2 reduction to solid carbon species on liquid metals featuring atomically thin ceria interfaces

Dorna Esrafilzadeh, Ali Zavabeti, Rouhollah Jalili, Paul Atkin, Jaecheol Choi, Benjamin J Carey, Robert Brkljaca, Anthony P O'Mullane, Michael D Dickey, David L Officer, Douglas R MacFarlane, Torben Daeneke, Kourosh Kalantar-Zadeh

2019-02-26

Negative carbon emission technologies are critical for ensuring a future stable climate. However, the gaseous state of CO2 does re..

Clinically Amendable, Defined, and Rapid Induction of Human Brain Organoids from Induced Pluripotent Stem Cells

Eva Tomaskovic-Crook, Jeremy M Crook

2019-01-01

Human brain organoids provide opportunities to produce three-dimensional (3D) brain-like tissues for biomedical research and trans..

A "Tandem" Strategy to Fabricate Flexible Graphene/Polypyrrole Nanofiber Film Using the Surfactant-Exfoliated Graphene for Supercapacitors

Kewei Shu, Yunfeng Chao, Shulei Chou, Caiyun Wang, Tian Zheng, Sanjeev Gambhir, Gordon G Wallace

2018-07-04

The surfactant-assisted liquid-phase exfoliation of expanded graphite can produce graphene sheets in large quantities with minimal..

Biomaterials for corneal bioengineering

Zhi Chen, Jingjing You, Xiao Liu, Simon Cooper, Christopher Hodge, Gerard Sutton, Jeremy M Crook, Gordon G Wallace

2018-05-01

Corneal transplantation is an important surgical treatment for many common corneal diseases. However, a worldwide shortage of tiss..

PEDOT doped with algal, mammalian and synthetic dopants: polymer properties, protein and cell interactions, and influence of electrical stimulation on neuronal cell differentiation

PJ Molino, L Garcia, EM Stewart, M Lamaze, B Zhang, AR Harris, P Winberg, GG Wallace

2018-05-01

Poly(3,4-ethylenedioxythiophene) (PEDOT) films were electrochemically polymerised with several synthetic (dodecylbenzosulfonic aci..

Fabrication and In Vitro Characterization of Electrochemically Compacted Collagen/Sulfated Xylorhamnoglycuronan Matrix for Wound Healing Applications

Lingzhi Kang, Xiao Liu, Zhilian Yue, Zhi Chen, Chris Baker, Pia C Winberg, Gordon G Wallace

2018-04-01

Skin autografts are in great demand due to injuries and disease, but there are challenges using live tissue sources, and synthetic..

Organic Electrodes and Communications with Excitable Cells

Alexander R Harris, Gordon G Wallace

2018-03-21

Electrodes can provide information on neural function and stimulate neural activity. These neural electrodes can provide remarkabl..

Conductive Tough Hydrogel for Bioapplications

Mohammad Javadi, Qi Gu, Sina Naficy, Syamak Farajikhah, Jeremy M Crook, Gordon G Wallace, Stephen Beirne, Simon E Moulton

2018-02-01

Biocompatible conductive tough hydrogels represent a new class of advanced materials combining the properties of tough hydrogels a..

Three-dimensional neural cultures produce networks that mimic native brain activity

Justin L Bourke, Anita F Quigley, Serena Duchi, Cathal D O'Connell, Jeremy M Crook, Gordon G Wallace, Mark J Cook, Robert MI Kapsa

2018-02-01

Development of brain function is critically dependent on neuronal networks organized through three dimensions. Culture of central ..

Advanced fabrication approaches to controlled delivery systems for epilepsy treatment

Gilles Sebastiaan van Tienderen, Marius Berthel, Zhilian Yue, Mark Cook, Xiao Liu, Stephen Beirne, Gordon G Wallace

2018-01-01

INTRODUCTION: Epilepsy is a chronic brain disease characterized by unprovoked seizures, which can have severe consequences includi..

Innovative Cartilage Regeneration for in situ Co-axial 3D Bioprinting

S Duchi, C Onofrillo, CD O'Connell, R Blanchard, AF Quigley, RM Kapsa, GG Wallace, C Di Bella, PF Choong

2017-12-01

Development of a porous 3D graphene-PDMS scaffold for improved osseointegration

Jianfeng Li, Xiao Liu, Jeremy M Crook, Gordon G Wallace

2017-11-01

Osseointegration in orthopedic surgery plays an important role for bone implantation success. Traditional treatment of implant sur..

3D Bioprinting Human Induced Pluripotent Stem Cell Constructs for In Situ Cell Proliferation and Successive Multilineage Differentiation

Qi Gu, Eva Tomaskovic-Crook, Gordon G Wallace, Jeremy M Crook

2017-09-06

The ability to create 3D tissues from induced pluripotent stem cells (iPSCs) is poised to revolutionize stem cell research and reg..

Evaluation of the Biocompatibility of Polypyrrole Implanted Subdurally in GAERS

Sebastien H Bauquier, Karen J McLean, Jonathan L Jiang, Ray C Boston, Alan Lai, Zhilian Yue, Simon E Moulton, Amy J Halliday, Gordon Wallace, Mark J Cook

2017-05-01

This blinded controlled prospective randomized study investigates the biocompatibility of polypyrrole (PPy) polymer that will be u..

Effective Area and Charge Density of Iridium Oxide Neural Electrodes

Alexander R Harris, Antonio G Paolini, Gordon G Wallace

2017-03-10

The effective electrode area and charge density of iridium metal and anodically activated iridium has been measured by optical and..

Electrical Stimulation Using Conductive Polymer Polypyrrole Counters Reduced Neurite Outgrowth of Primary Prefrontal Cortical Neurons from NRG1-KO and DISC1-LI Mice

Qingsheng Zhang, Dorna Esrafilzadeh, Jeremy M Crook, Robert Kapsa, Elise M Stewart, Eva Tomaskovic-Crook, Gordon G Wallace, Xu-Feng Huang

2017-02-15

Deficits in neurite outgrowth, possibly involving dysregulation of risk genes neuregulin-1 (NRG1) and disrupted in schizophrenia 1..

Correlation of Impedance and Effective Electrode Area of Iridium Oxide Neural Electrodes

Alexander R Harris, Antonio G Paolini

2017-01-01

Iridium oxide is routinely used for bionic applications owing to its high charge injection capacity. The electrode impedance at 1k..

Correlation of impedance and effective electrode area of chondroitin sulphate doped PEDOT modified electrodes

Alexander R Harris, Paul J Molino, Antonio G Paolini, Gordon G Wallace

2016-12-01

Neural electrode arrays were coated with PEDOT doped with chondroitin sulphate. The impedance of the individually addressable micr..

Effective area and charge density of dextran sulphate doped PEDOT modified electrodes

Alexander R Harris, Paul J Molino, Robert MI Kapsa, Graeme M Clark, Antonio G Paolini, Gordon G Wallace

2016-10-01

The performance of neural electrodes over chronic periods is poor with degrading signal-to-noise ratio and low biocompatibility. C..

Functional 3D Neural Mini-Tissues from Printed Gel-Based Bioink and Human Neural Stem Cells

Qi Gu, Eva Tomaskovic-Crook, Rodrigo Lozano, Yu Chen, Robert M Kapsa, Qi Zhou, Gordon G Wallace, Jeremy M Crook

2016-06-22

Direct-write printing of stem cells within biomaterials presents an opportunity to engineer tissue for in vitro modeling and regen..

Effective Area and Charge Density of Chondroitin Sulphate Doped PEDOT Modified Electrodes

Alexander R Harris, Paul J Molino, Antonio G Paolini, Gordon G Wallace

2016-04-10

Neural electrodes have been coated with electrodeposited poly-3,4-ethylenedioxythiophene doped with chondroitin sulphate. Optical ..

Conductive and protein resistant polypyrrole films for dexamethasone delivery

B Zhang, PJ Molino, AR Harris, Z Yue, SE Moulton, GG Wallace

2016-01-01

The development of inherently conducting polymers as controllable/programmable drug delivery systems has attracted significant int..

Correlation of Impedance and Effective Electrode Area of Dextran Sulfate Doped PEDOT Modified Electrodes

Alexander R Harris, Robyn Hutchinson, Paul J Molino, Robert MI Kapsa, Graeme M Clark, Antonio G Paolini, Gordon G Wallace

2016-01-01

The impedance of electrodes at 1 kHz is typically reported to assess the signal-to-noise ratio of neural recording electrodes. The..

Thin-film micro-electrode stimulation of the cochlea in rats exposed to aminoglycoside induced hearing loss

BJ Allitt, AR Harris, SJ Morgan, GM Clark, AG Paolini

2016-01-01

The multi-channel cochlear implant (CI) provides sound and speech perception to thousands of individuals who would otherwise be de..

Recent advances in nerve tissue engineering

Bill GX Zhang, Anita F Quigley, Damian E Myers, Gordon G Wallace, Robert MI Kapsa, Peter FM Choong

2014-04-01

Nerve injury secondary to trauma, neurological disease or tumor excision presents a challenge for surgical reconstruction. Current..