ARC CENTRE OF EXCELLENCE IN CONVERGENT BIO–NANO SCIENCE AND TECHNOLOGY
Grant number: CE140100036 | Funding period: 2014 - 2021
The CoE in Convergent Bio-Nano Science &Technology comprises a multi-disciplinary team focused on research aiming to understand and control the interface of materials with biological systems. The Centre will exploit knowledge of the bio-nano interface to design materials that transport and deliver vaccines, drugs and gene therapy agents, and to design new diagnostic agents and devices. Nanomedicines are on the cusp of revolutionizing diagnosis and therapy in many diseases. The CoE will be the focus of bio-nano research activity in Australia, uniting universities, research agencies, institutes and companies. The expected outcomes are better diagnostic and therapeutic tools designed via an..View full description
Related publications (114)
Stereoselective Growth of Small Molecule Patches on Nanoparticles
Jiajing Zhou, Matthew N Creyer, Amanda Chen, Wonjun Yim, Rene PM Lafleur, Tengyu He, Zhixing Lin, Ming Xu, Pedram Abbasi, Jianfeng Wu, Tod A Pascal, Frank Caruso, Jesse V Jokerst
Patchy nanoparticles featuring tunable surface domains with spatial and chemical specificity are of fundamental interest, especial..
Robust and Versatile Coatings Engineered via Simultaneous Covalent and Noncovalent Interactions
Jiajing Zhou, Matthew Penna, Zhixing Lin, Yiyuan Han, Rene PM Lafleur, Yijiao Qu, Joseph J Richardson, Irene Yarovsky, Jesse V Jokerst, Frank Caruso
Interfacial modular assembly has emerged as an adaptable strategy for engineering the surface properties of substrates in biomedic..
Quantitatively Tracking Bio-Nano Interactions of Metal-Phenolic Nanocapsules by Mass Cytometry
Shiyao Li, Yi Ju, Jiajing Zhou, Ka Fung Noi, Andrew J Mitchell, Tian Zheng, Stephen J Kent, Christopher JH Porter, Frank Caruso
Polymer nanocapsules, with a hollow structure, are increasingly finding widespread use as drug delivery carriers; however, quantit..
Fluorinated Metal-Organic Coatings with Selective Wettability
Shuaijun Pan, Joseph J Richardson, Andrew J Christofferson, Quinn A Besford, Tian Zheng, Barry J Wood, Xiaofei Duan, Maximiliano Jesus Jara Fornerod, Christopher F McConville, Irene Yarovsky, Stefan Guldin, Lei Jiang, Frank Caruso
Surface chemistry is a major factor that determines the wettability of materials, and devising broadly applicable coating strategi..
A Focus on "Bio" in Bio-Nanoscience: The Impact of Biological Factors on Nanomaterial Interactions
Christina Cortez-Jugo, Ewa Czuba-Wojnilowicz, Abigail Tan, Frank Caruso
Bio-nanoscience research encompasses studies on the interactions of nanomaterials with biological structures or what is commonly r..
Influence of Poly(ethylene glycol) Molecular Architecture on Particle Assembly and Ex Vivo Particle-Immune Cell Interactions in Human Blood
Jiaying Song, Yi Ju, Thakshila H Amarasena, Zhixing Lin, Srinivas Mettu, Jiajing Zhou, Md Arifur Rahim, Ching-Seng Ang, Christina Cortez-Jugo, Stephen J Kent, Frank Caruso
Poly(ethylene glycol) (PEG) is widely used in particle assembly to impart biocompatibility and stealth-like properties in vivo for..
Exploiting Supramolecular Dynamics in Metal-Phenolic Networks to Generate Metal-Oxide and Metal-Carbon Networks
Shuaijun Pan, Eirini Goudeli, Jingqu Chen, Zhixing Lin, Qi-Zhi Zhong, Wenjie Zhang, Haitao Yu, Rui Guo, Joseph J Richardson, Frank Caruso
Supramolecular complexation is a powerful strategy for engineering materials in bulk and at interfaces. Metal-phenolic networks (M..
In Vivo T Cell-Targeting Nanoparticle Drug Delivery Systems: Considerations for Rational Design
Paula M Cevaal, Abdalla Ali, Ewa Czuba-Wojnilowicz, Jori Symons, Sharon R Lewin, Christina Cortez-Jugo, Frank Caruso
T cells play an important role in immunity and repair and are implicated in diseases, including blood cancers, viral infections, a..
X-ray-Based Techniques to Study the Nano-Bio Interface
Carlos Sanchez-Cano, Ramon A Alvarez-Puebla, John M Abendroth, Tobias Beck, Robert Blick, Yuan Cao, Frank Caruso, Indranath Chakraborty, Henry N Chapman, Chunying Chen, Bruce E Cohen, Andre LC Conceição, David P Cormode, Daxiang Cui, Kenneth A Dawson, Gerald Falkenberg, Chunhai Fan, Neus Feliu, Mingyuan Gao, Elisabetta Gargioni
X-ray-based analytics are routinely applied in many fields, including physics, chemistry, materials science, and engineering. The ..
Microemulsion-Assisted Templating of Metal-Stabilized Poly(ethylene glycol) Nanoparticles
Gan Lin, Christina Cortez-Jugo, Yi Ju, Quinn A Besford, Timothy M Ryan, Shuaijun Pan, Joseph J Richardson, Frank Caruso
Poly(ethylene glycol) (PEG) is well known to endow nanoparticles (NPs) with low-fouling and stealth-like properties that can reduc..
Metal–Phenolic Networks as Tunable Buffering Systems
Jingqu Chen, Shuaijun Pan, Jiajing Zhou, Robert Seidel, Sebastian Beyer, Zhixing Lin, Joseph J Richardson, Frank Caruso
The buffering effects displayed by pH‐responsive polymers have recently gained attention in diverse fields such as nanomedicine an..
Catalytically Active Copper Phosphate-Dextran Sulfate Microparticle Coatings for Bioanalyte Sensing
Pietro Pacchin Tomanin, Sukhvir Kaur Bhangu, Frank Caruso, Francesca Cavalieri
Engineering reactive and functional nanostructured surfaces is important for enhancing the sensitivity and versatility of biosenso..
Engineered Coatings via the Assembly of Amino-Quinone Networks
Qi-Zhi Zhong, Joseph J Richardson, Ai He, Tian Zheng, Rene PM Lafleur, Jianhua Li, Wen-Ze Qiu, Denzil Furtado, Shuaijun Pan, Zhi-Kang Xu, Ling-Shu Wan, Frank Caruso
Engineering coatings with precise physicochemical properties allows for control over the interface of a material and its interacti..
Person-Specific Biomolecular Coronas Modulate Nanoparticle Interactions with Immune Cells in Human Blood
Yi Ju, Hannah G Kelly, Laura F Dagley, Arnold Reynaldi, Timothy E Schlub, Sukhdeep K Spall, Craig A Bell, Jiwei Cui, Andrew J Mitchell, Zhixing Lin, Adam K Wheatley, Kristofer J Thurecht, Miles P Davenport, Andrew Webb, Frank Caruso, Stephen J Kent
When nanoparticles interact with human blood, a multitude of plasma components adsorb onto the surface of the nanoparticles, formi..
Particle engineering enabled by polyphenol-mediated supramolecular networks.
Jiajing Zhou, Zhixing Lin, Matthew Penna, Shuaijun Pan, Yi Ju, Shiyao Li, Yiyuan Han, Jingqu Chen, Gan Lin, Joseph J Richardson, Irene Yarovsky, Frank Caruso
We report a facile strategy for engineering diverse particles based on the supramolecular assembly of natural polyphenols and a se..
Dynamic Electrophoretic Assembly of Metal–Phenolic Films: Accelerated Formation and Cytocompatible Detachment
Gyeongwon Yun, Wongu Youn, Hojae Lee, Sang Yeong Han, Mariana B Oliveira, Hyeoncheol Cho, Frank Caruso, João F Mano, Insung S Choi
Material-independent coating has emerged as an advanced tool for interface engineering in numerous applications, including drug de..
Protein Component of Oyster Glycogen Nanoparticles: An Anchor Point for Functionalization
Quinn A Besford, Alessia CG Weiss, Jonas Schubert, Timothy M Ryan, Manfred F Maitz, Pietro Pacchin Tomanin, Marco Savioli, Carsten Werner, Andreas Fery, Frank Caruso, Francesca Cavalieri
Biosourced nanoparticles have a range of desirable properties for therapeutic applications, including biodegradability and low imm..
Programmable Permeability of Metal–Phenolic Network Microcapsules
Jingqu Chen, Shuaijun Pan, Jiajing Zhou, Qi-Zhi Zhong, Yijiao Qu, Joseph J Richardson, Frank Caruso
Developing materials with programmable permeability for cargo encapsulation and release is challenging but important in a number o..
Template-Mediated Assembly of DNA into Microcapsules for Immunological Modulation
Yijiao Qu, Yi Ju, Christina Cortez-Jugo, Zhixing Lin, Shiyao Li, Jiajing Zhou, Yutian Ma, Agata Glab, Stephen J Kent, Francesca Cavalieri, Frank Caruso
There is a need for effective vaccine delivery systems and vaccine adjuvants without extraneous excipients that can compromise or ..
Distribution of Particles in Human Stem Cell-Derived 3D Neuronal Cell Models: Effect of Particle Size, Charge, and Density
Ewa Czuba-Wojnilowicz, Sara Miellet, Agata Glab, Serena Viventi, Francesca Cavalieri, Christina Cortez-Jugo, Mirella Dottori, Frank Caruso
Neurodegenerative diseases are generally characterized by a progressive loss of neuronal subpopulations, with no available cure to..
Dissecting the intracellular signalling and fate of a DNA nanosensor by super-resolution and quantitative microscopy.
Agata Glab, Alessandro Bertucci, Fabiana Martino, Marcin Wojnilowicz, Alessia Amodio, Mariano Venanzi, Francesco Ricci, Giancarlo Forte, Frank Caruso, Francesca Cavalieri
DNA nanodevices have been developed as platforms for the manipulation of gene expression, delivery of molecular payloads, and dete..
Nanoengineering multifunctional hybrid interfaces using adhesive glycogen nanoparticles.
Pietro Pacchin Tomanin, Jiajing Zhou, Alessia Amodio, Rita Cimino, Agata Glab, Francesca Cavalieri, Frank Caruso
Multifunctional and biodegradable nanostructured hybrid interfaces based on biopolymers are potentially useful in many application..
Surface Modification of Spider Silk Particles to Direct Biomolecular Corona Formation.
Alessia CG Weiss, Heike M Herold, Sarah Lentz, Matthew Faria, Quinn A Besford, Ching-Seng Ang, Frank Caruso, Thomas Scheibel
In recent years, spider silk-based materials have attracted attention because of their biocompatibility, processability, and biode..
Modulating the Selectivity and Stealth Properties of Ellipsoidal Polymersomes through a Multivalent Peptide Ligand Display
Kristel C Tjandra, Chelsea R Forest, Chin Ken Wong, Sheilajen Alcantara, Hannah G Kelly, Yi Ju, Martina H Stenzel, Joshua A McCarroll, Maria Kavallaris, Frank Caruso, Stephen J Kent, Pall Thordarson
There is a need for improved nanomaterials to simultaneously target cancer cells and avoid non‐specific clearance by phagocytes. A..
Sulfoxide-Containing Polymer-Coated Nanoparticles Demonstrate Minimal Protein Fouling and Improved Blood Circulation
Ruirui Qiao, Changkui Fu, Yuhuan Li, Xiaole Qi, Dalong Ni, Aparna Nandakumar, Ghizal Siddiqui, Haiyan Wang, Zheng Zhang, Tingting Wu, Jian Zhong, Shi-Yang Tang, Shuaijun Pan, Cheng Zhang, Michael R Whittaker, Jonathan W Engle, Darren J Creek, Frank Caruso, Pu Chun Ke, Weibo Cai
Minimizing the interaction of nanomedicines with the mononuclear phagocytic system (MPS) is a critical challenge for their clinica..
Particle-mediated delivery of frataxin plasmid to a human sensory neuronal model of Friedreich's ataxia.
Ewa Czuba-Wojnilowicz, Serena Viventi, Sara E Howden, Simon Maksour, Amy E Hulme, Christina Cortez-Jugo, Mirella Dottori, Frank Caruso
Increasing frataxin protein levels through gene therapy is envisaged to improve therapeutic outcomes for patients with Friedreich'..
Engineering of Nebulized Metal-Phenolic Capsules for Controlled Pulmonary Deposition
Yi Ju, Christina Cortez-Jugo, Jingqu Chen, Ting-Yi Wang, Andrew J Mitchell, Evelyn Tsantikos, Nadja Bertleff-Zieschang, Yu-Wei Lin, Jiaying Song, Yizhe Cheng, Srinivas Mettu, Md Arifur Rahim, Shuaijun Pan, Gyeongwon Yun, Margaret L Hibbs, Leslie Y Yeo, Christoph E Hagemeyer, Frank Caruso
Particle-based pulmonary delivery has great potential for delivering inhalable therapeutics for local or systemic applications. Th..
Cobalt-Directed Assembly of Antibodies onto Metal-Phenolic Networks for Enhanced Particle Targeting.
Wenjie Zhang, Quinn A Besford, Andrew J Christofferson, Patrick Charchar, Joseph J Richardson, Aaron Elbourne, Kristian Kempe, Christoph E Hagemeyer, Matthew R Field, Chris F McConville, Irene Yarovsky, Frank Caruso
The orientation-specific immobilization of antibodies onto nanoparticles, to preserve antibody-antigen recognition, is a key chall..
Polyphenol-Mediated Assembly of Proteins for Engineering Functional Materials
Yiyuan Han, Zhixing Lin, Jiajing Zhou, Gyeongwon Yun, Rui Guo, Joseph J Richardson, Frank Caruso
Functional materials composed of proteins have attracted much interest owing to the inherent and diverse functionality of proteins..
Self-Assembly of a Metal-Phenolic Sorbent for Broad-Spectrum Metal Sequestration
Md Arifur Rahim, Gan Lin, Pietro Pacchin Tomanin, Yi Ju, Anders Barlow, Mattias Bjornmalm, Frank Caruso
Metal contamination of water bodies from industrial effluents presents a global threat to the aquatic ecosystem. To address this c..
The Biomolecular Corona in 2D and Reverse: Patterning Metal–Phenolic Networks on Proteins, Lipids, Nucleic Acids, Polysaccharides, and Fingerprints
G Yun, JJ Richardson, M Capelli, Y Hu, QA Besford, ACG Weiss, H Lee, IS Choi, BC Gibson, P Reineck, F Caruso
The adsorption of biomolecules onto nanomaterials can alter the performance of the nanomaterials in vitro and in vivo. Recent stud..
Modular Assembly of Host-Guest Metal-Phenolic Networks Using Macrocyclic Building Blocks
Shuaijun Pan, Rui Guo, Nadja Bertleff-Zieschang, Shanshan Li, Quinn A Besford, Qi-Zhi Zhong, Gyeongwon Yun, Yunti Zhang, Francesca Cavalieri, Yi Ju, Eirini Goudeli, Joseph J Richardson, Frank Caruso
The manipulation of interfacial properties has broad implications for the development of high‐performance coatings. Metal–phenolic..
A radiolabeled drug tracing method to study neurotrophin-3 retention and distribution in the cochlea after nano-based local delivery
Patrick Lam, Niliksha Gunewardene, Yutian Ma, Frank Caruso, Nguyen Trung, Brianna Flynn, Andrew K Wise, Rachael T Richardson
Hearing loss is the most common sensory deficit worldwide with no approved therapeutics for treatment. Local neurotrophin delivery..
Expanding the Toolbox of Metal-Phenolic Networks via Enzyme-Mediated Assembly
Qi-Zhi Zhong, Joseph J Richardson, Shiyao Li, Wenjie Zhang, Yi Ju, Jianhua Li, Shuaijun Pan, Jingqu Chen, Frank Caruso
Functional coatings are of considerable interest because of their fundamental implications for interfacial assembly and promise fo..
Metal-Phenolic Coatings as a Platform to Trigger Endosomal Escape of Nanoparticles.
Jingqu Chen, Jianhua Li, Jiajing Zhou, Zhixing Lin, Francesca Cavalieri, Ewa Czuba-Wojnilowicz, Yingjie Hu, Agata Glab, Yi Ju, Joseph J Richardson, Frank Caruso
The intracellular delivery of functional nanoparticles (NPs) and the release of therapeutic payloads at a target site are central ..
Assessing Cardiomyocyte Excitation-Contraction Coupling Site Detection From Live Cell Imaging Using a Structurally-Realistic Computational Model of Calcium Release
David Ladd, Agne Tilunaite, H Llewelyn Roderick, Christian Soeller, Edmund J Crampin, Vijay Rajagopal
Calcium signaling plays a pivotal role in cardiomyocytes, coupling electrical excitation to mechanical contraction of the heart. D..
Ricocheting Droplets Moving on Super-Repellent Surfaces
Shuaijun Pan, Rui Guo, Joseph J Richardson, Joseph D Berry, Quinn A Besford, Mattias Bjornmalm, Gyeongwon Yun, Ruoxi Wu, Zhixing Lin, Qi-Zhi Zhong, Jiajing Zhou, Qiang Sun, Jianhua Li, Yanbing Lu, Zhichao Dong, Margaret Katherine Banks, Weijian Xu, Jianhui Jiang, Lei Jiang, Frank Caruso
Droplet bouncing on repellent solid surfaces (e.g., the lotus leaf effect) is a common phenomenon that has aroused interest in var..
Engineering Biocoatings To Prolong Drug Release from Supraparticles
Yutian Ma, Christina Cortez-Jugo, Jianhua Li, Zhixing Lin, Rachael T Richardson, Yiyuan Han, Jiajing Zhou, Mattias Bjornmalm, Orlagh M Feeney, Qi-Zhi Zhong, Christopher JH Porter, Andrew K Wise, Frank Caruso
Supraparticles (SPs) assembled from smaller colloidal nanoparticles can serve as depots of therapeutic compounds and are of intere..
Oxidation-Mediated Kinetic Strategies for Engineering Metal-Phenolic Networks
Qi-Zhi Zhong, Shiyao Li, Jingqu Chen, Ke Xie, Shuaijun Pan, Joseph J Richardson, Frank Caruso
The tunable growth of metal–organic materials has implications for engineering particles and surfaces for diverse applications. Sp..
Revisiting cell-particle association in vitro: A quantitative method to compare particle performance.
Matthew Faria, Ka Fung Noi, Qiong Dai, Mattias Björnmalm, Stuart T Johnston, Kristian Kempe, Frank Caruso, Edmund J Crampin
Nanoengineering has the potential to revolutionize medicine by designing drug delivery systems that are both efficacious and highl..
Cellular Targeting of Bispecific Antibody-Functionalized Poly(ethylene glycol) Capsules: Do Shape and Size Matter?
Danzi Song, Jiwei Cui, Yi Ju, Matthew Faria, Huanli Sun, Christopher B Howard, Kristofer J Thurecht, Frank Caruso
In the present study, a capsule system that consists of a stealth carrier based on poly(ethylene glycol) (PEG) and functionalized ..
Template-Free Synthesis of Chemically Asymmetric Silica Nanotubes for Selective Cargo Loading and Sustained Drug Release
Chao Deng, Qian Zhang, Cong Fu, Fangzhou Zhou, Wuli Yang, Deliang Yi, Xingdong Wang, Yi Tang, Frank Caruso, Yajun Wang
SiO2 nanotubes (NTs), with uniform diameter (∼25 nm) and tailored shell thickness (1–5 nm), and featuring chemically asymmetric su..
SupraCells: Living Mammalian Cells Protected within Functional Modular Nanoparticle-Based Exoskeletons
Wei Zhu, Jimin Guo, Shahrouz Amini, Yi Ju, Jacob Ongudi Agola, Andreas Zimpel, Jin Shang, Achraf Noureddine, Frank Caruso, Stefan Wuttke, Jonas G Croissant, C Jeffrey Brinker
Creating a synthetic exoskeleton from abiotic materials to protect delicate mammalian cells and impart them with new functionaliti..
The Future of Layer-by-Layer Assembly: A Tribute to ACS Nano Associate Editor Helmuth Mohwald
Shuang Zhao, Frank Caruso, Lars Daehne, Gero Decher, Bruno G De Geest, Jinchen Fan, Neus Feliu, Yury Gogotsi, Paula T Hammond, Mark C Hersam, Ali Khademhosseini, Nicholas Kotov, Stefano Leporatti, Yan Li, Fred Lisdat, Luis M Liz-Marzan, Sergio Moya, Paul Mulvaney, Andrey L Rogach, Sathi Roy
Layer-by-layer (LbL) assembly is a widely used tool for engineering materials and coatings. In this Perspective, dedicated to the ..
Selective Metal-Phenolic Assembly from Complex Multicomponent Mixtures
Gan Lin, Md Arifur Rahim, Michael G Leeming, Christina Cortez-Jugo, Quinn A Besford, Yi Ju, Qi-Zhi Zhong, Stuart T Johnston, Jiajing Zhou, Frank Caruso
Selective self-assembly in multicomponent mixtures offers a method for isolating desired components from complex systems for the r..
Modulating Targeting of Poly(ethylene glycol) Particles to Tumor Cells Using Bispecific Antibodies
Jiwei Cui, Yi Ju, Zachary H Houston, Joshua J Class, Nicholas L Fletcher, Sheilajen Alcantara, Qiong Dai, Christopher B Howard, Stephen M Mahler, Adam K Wheatley, Robert De Rose, Paul T Brannon, Brett M Paterson, Paul S Donnelly, Kristoferj Thurecht, Frank Caruso, Stephen J Kent
Low-fouling or "stealth" particles composed of poly(ethylene glycol) (PEG) display a striking ability to evade phagocytic cell upt..
Modular Metal-Organic Polyhedra Superassembly: From Molecular-Level Design to Targeted Drug Delivery
Wei Zhu, Jimin Guo, Yi Ju, Rita E Serda, Jonas G Croissant, Jin Shang, Eric Coker, Jacob Ongudi Agola, Qi-Zhi Zhong, Yuan Ping, Frank Caruso, C Jeffrey Brinker
Targeted drug delivery remains at the forefront of biomedical research but remains a challenge to date. Herein, the first superass..
Perturbation of mucosal-associated invariant T cells and iNKT cells in HIV infection
Jennifer A Juno, Chansavath Phetsouphanh, Paul Klenerman, Stephen J Kent
PURPOSE OF REVIEW: To analyze the possible role that the 'unconventional' T-cell populations mucosal-associated invariant T cell (..
Protein Adsorption and Coordination-Based End-Tethering of Functional Polymers on Metal-Phenolic Network Films
Blaise L Tardy, Joseph J Richardson, Vichida Nithipipat, Kristian Kempe, Junling Guo, Kwun Lun Cho, Md Arifur Rahim, Hirotaka Ejima, Frank Caruso
Metal-phenolic network (MPN) coatings have generated increasing interest owing to their biologically inspired nature, facile fabri..
Tuning the Mechanical Behavior of Metal-Phenolic Networks through Building Block Composition
Gyeongwon Yun, Joseph J Richardson, Matthew Biviano, Frank Caruso
Metal-phenolic networks (MPNs) are an emerging class of functional metal-organic materials with a high degree of modularity in ter..
Metal-dependent inhibition of amyloid fibril formation: synergistic effects of cobalt-tannic acid networks
Wenjie Zhang, Andrew J Christofferson, Quinn A Besford, Joseph J Richardson, Junling Guo, Yi Ju, Kristian Kempe, Irene Yarovsky, Frank Caruso
Metal-phenolic networks (MPNs) have received widespread interest owing to their modular incorporation of functional metal ions and..
Ligand-Functionalized Poly(ethylene glycol) Particles for Tumor Targeting and Intracellular Uptake.
Jiwei Cui, Karen Alt, Yi Ju, Sylvia T Gunawan, Julia A Braunger, Ting-Yi Wang, Yunlu Dai, Qiong Dai, Joseph J Richardson, Junling Guo, Mattias Björnmalm, Christoph E Hagemeyer, Frank Caruso
Drug carriers typically require both stealth and targeting properties to minimize nonspecific interactions with healthy cells and ..
Cobalt Phosphate Nanostructures for Non-Enzymatic Glucose Sensing at Physiological pH
Pietro Pacchin Tomanin, Pavel V Cherepanov, Quinn A Besford, Andrew J Christofferson, Alessia Amodio, Chris F McConville, Irene Yarovsky, Frank Caruso, Francesca Cavalieri
Nanostructured materials have potential as platforms for analytical assays and catalytic reactions. Herein, we report the synthesi..
Overcoming the Blood-Brain Barrier: The Role of Nanomaterials in Treating Neurological Diseases
Denzil Furtado, Mattias Bjornmalm, Scott Ayton, Ashley I Bush, Kristian Kempe, Frank Caruso
Therapies directed toward the central nervous system remain difficult to translate into improved clinical outcomes. This is largel..
Coatings super-repellent to ultralow surface tension liquids
Shuaijun Pan, Rui Guo, Mattias Bjornmalm, Joseph J Richardson, Ling Li, Chang Peng, Nadja Bertleff-Zieschang, Weijian Xu, Jianhui Jiang, Frank Caruso
High-performance coatings that durably and fully repel liquids are of interest for fundamental research and practical applications..
Spray Assembly of Metal-Phenolic Networks: Formation, Growth, and Applications
Qi-Zhi Zhong, Shuaijun Pan, Md Arifur Rahim, Gyeongwon Yun, Jianhua Li, Yi Ju, Zhixing Lin, Yiyuan Han, Yutian Ma, Joseph J Richardson, Frank Caruso
Hybrid conformal coatings, such as metal-phenolic networks (MPNs) that are constructed from the coordination-driven assembly of na..
Gel-Mediated Electrospray Assembly of Silica Supraparticles for Sustained Drug Delivery
Yutian Ma, Mattias Bjoernmalm, Andrew K Wise, Christina Cortez-Jugo, Eve Revalor, Yi Ju, Orlagh M Feeney, Rachael T Richardson, Eric Hanssen, Robert K Shepherd, Christopher JH Porter, Frank Caruso
Supraparticles (SPs) composed of smaller colloidal particles provide a platform for the long-term, controlled release of therapeut..
Minimum information reporting in bio-nano experimental literature
Matthew Faria, Mattias Bjornmalm, Kristofer J Thurecht, Stephen J Kent, Robert G Parton, Maria Kavallaris, Angus PR Johnston, J Justin Gooding, Simon R Corrie, Ben J Boyd, Pall Thordarson, Andrew K Whittaker, Molly M Stevens, Clive A Prestidge, Christopher JH Porter, Wolfgang J Parak, Thomas P Davis, Edmund J Crampin, Frank Caruso
Studying the interactions between nanoengineered materials and biological systems plays a vital role in the development of biologi..
An analytical approach for quantifying the influence of nanoparticle polydispersity on cellular delivered dose
Stuart T Johnston, Matthew Faria, Edmund J Crampin
Nanoparticles provide a promising approach for the targeted delivery of therapeutic, diagnostic and imaging agents in the body. Ho..
Low-Fouling and Biodegradable Protein-Based Particles for Thrombus Imaging
Thomas Bonnard, Anand Jayapadman, Jasmine A Putri, Jiwei Cui, Yi Ju, Catherine Carmichael, Thomas A Angelovich, Stephen H Cody, Shauna French, Karline Pascaud, Hannah A Pearce, Shweta Jagdale, Frank Caruso, Christoph E Hagemeyer
Nanomedicine holds great promise for vascular disease diagnosis and specific therapy, yet rapid sequestration by the mononuclear p..
Microfluidic Examination of the "Hard" Biomolecular Corona Formed on Engineered Particles in Different Biological Milieu
Alessia CG Weiss, Kristian Kempe, Stephan Foerster, Frank Caruso
The formation of a biomolecular corona around engineered particles determines, in large part, their biological behavior in vitro a..
Human plasma proteome association and cytotoxicity of nano-graphene oxide grafted with stealth polyethylene glycol and poly(2-ethyl-2oxazoline)
Miaoyi Wang, Ove JR Gustafsson, Ghizal Siddiqui, Ibrahim Javed, Hannah G Kelly, Thomas Blin, Hong Yin, Stephen J Kent, Darren J Creek, Kristian Kempe, Pu Chun Ke, Thomas P Davis
Polyethylene glycol (PEG) is a gold standard against protein fouling. However, recent studies have revealed surprising adverse eff..
Identification of Native and Posttranslationally Modified HLA-B*57:01-Restricted HIV Envelope Derived Epitopes Using Immunoproteomics
Sri H Ramarathinam, Stephanie Gras, Sheilajen Alcantara, Amanda WS Yeung, Nicole A Mifsud, Secondo Sonza, Patricia T Illing, Elias N Glaros, Robert J Center, Shane R Thomas, Stephen J Kent, Nicola Ternette, Damian FJ Purcell, Jamie Rossjohn, Anthony W Purcell
The recognition of pathogen‐derived peptides by T lymphocytes is the cornerstone of adaptive immunity, whereby intracellular antig..
A unique F-19 MRI agent for the tracking of non phagocytic cells in vivo
Shehzahdi S Moonshi, Cheng Zhang, Hui Peng, Simon Puttick, Stephen Rose, Nicholas M Fisk, Kishore Bhakoo, Brett W Stringer, Greg G Qiao, Paul A Gurr, Andrew K Whittaker
There is currently intense interest in new methods for understanding the fate of therapeutically-relevant cells, such as mesenchym..
Multiligand Metal-Phenolic Assembly from Green Tea Infusions
Md Arifur Rahim, Mattias Bjornmalm, Nadja Bertleff-Zieschang, Yi Ju, Srinivas Mettu, Michael G Leeming, Frank Caruso
The synthesis of hybrid functional materials using the coordination-driven assembly of metal-phenolic networks (MPNs) is of intere..
Electrochemical Behavior and Redox-Dependent Disassembly of Gallic Acid/Fe-III Metal-Phenolic Networks
Pavel V Cherepanov, Md Arifur Rahim, Nadja Bertleff-Zieschang, Md Abu Sayeed, Anthony P O'Mullane, Simon E Moulton, Frank Caruso
Metal-phenolic networks (MPNs) are a versatile class of organic-inorganic hybrid systems that are generating interest for applicat..
Particle Targeting in Complex Biological Media
Qiong Dai, Nadja Bertleff-Zieschang, Julia A Braunger, Mattias Bjornmalm, Christina Cortez-Jugo, Frank Caruso
Over the past few decades, nanoengineered particles have gained increasing interest for applications in the biomedical realm, incl..
Influence of Ionic Strength on the Deposition of Metal-Phenolic Networks
Junling Guo, Joseph J Richardson, Quinn A Besford, Andrew J Christofferson, Yunlu Dai, Chien W Ong, Blaise L Tardy, Kang Liang, Gwan H Choi, Jiwei Cui, Pil J Yoo, Irene Yarovsky, Frank Caruso
Metal-phenolic networks (MPNs) are a versatile class of self-assembled materials that are able to form functional thin films on va..
Self-Assembled Nanoparticles from Phenolic Derivatives for Cancer Therapy
Yunlu Dai, Junling Guo, Ting-Yi Wang, Yi Ju, Andrew J Mitchell, Thomas Bonnard, Jiwei Cui, Joseph J Richardson, Christoph E Hagemeyer, Karen Alt, Frank Caruso
Therapeutic nanoparticles hold clinical promise for cancer treatment by avoiding limitations of conventional pharmaceuticals. Here..
Rust-Mediated Continuous Assembly of Metal-Phenolic Networks
Md Arifur Rahim, Mattias Bjoernmalm, Nadja Bertleff-Zieschang, Quinn Besford, Srinivas Mettu, Tomoya Suma, Matthew Faria, Frank Caruso
The use of natural compounds for preparing hybrid molecular films-such as surface coatings made from metal-phenolic networks (MPNs..
Lactosylated Glycogen Nanoparticles for Targeting Prostate Cancer Cells
Quinn A Besford, Marcin Wojnilowicz, Tomoya Suma, Nadja Bertleff-Zieschang, Frank Caruso, Francesca Cayalieri
Glyconanoparticles that exhibit multivalent binding to lectins are desirable for molecular recognition and therapeutic application..
Modulated Fragmentation of Proapoptotic Peptide Nanoparticles Regulates Cytotoxicity
Tomoya Suma, Jiwei Cui, Markus Muellner, Shiwei Fu, Jenny Tran, Ka Fung Noi, Yi Ju, Frank Caruso
Peptides perform a diverse range of physiologically important functions. The formulation of nanoparticles directly from functional..
Engineered Hydrogen-Bonded Glycopolymer Capsules and Their Interactions with Antigen Presenting Cells
Kristian Kempe, Sue D Xiang, Paul Wilson, Md Arifur Rahim, Yi Ju, Michael R Whittaker, David M Haddleton, Magdalena Plebanski, Frank Caruso, Thomas P Davis
Hollow glycopolymer microcapsules were fabricated by hydrogen-bonded layer-by-layer (LbL) assembly, and their interactions with a ..
Cell-Conditioned Protein Coronas on Engineered Particles Influence Immune Responses
Qiong Dai, Junling Guo, Yan Yan, Ching-Seng Ang, Nadja Bertleff-Zieschang, Frank Caruso
A protein corona, which forms on engineered particles as soon as they are introduced into biological environments, is known to pro..
Nanoengineering Particles through Template Assembly
Mattias Bjoernmalm, Jiwei Cui, Nadja Berdeff-Zieschang, Danzi Song, Matthew Faria, Md Arifur Rahim, Frank Caruso
The nanoengineering of particles is of interest for both fundamental and applied science. How particles are made substantially aff..
Immunological Principles Guiding the Rational Design of Particles for Vaccine Delivery
Katelyn T Gause, Adam K Wheatley, Jiwei Cui, Yan Yan, Stephen J Kent, Frank Caruso
Despite the immense public health successes of immunization over the past century, effective vaccines are still lacking for global..
Void Engineering in Metal-Organic Frameworks via Synergistic Etching and Surface Functionalization
Ming Hu, Yi Ju, Kang Liang, Tomoya Suma, Jiwei Cui, Frank Caruso
The rational design and engineering of metal–organic framework (MOF) crystals with hollow features has been used for various appli..
Synthesis of Discrete Alkyl-Silica Hybrid Nanowires and Their Assembly into Nanostructured Superhydrophobic Membranes
Deliang Yi, Chenglong Xu, Ruidie Tang, Xuehua Zhang, Frank Caruso, Yajun Wang
We report the synthesis of highly flexible and mechanically robust hybrid silica nanowires (NWs) which can be used as novel buildi..
Jing M Ren, Thomas G McKenzie, Qiang Fu, Edgar HH Wong, Jiangtao Xu, Zesheng An, Sivaprakash Shanmugam, Thomas P Davis, Cyrille Boyer, Greg G Qiao
Recent advances in controlled/living polymerization techniques and highly efficient coupling chemistries have enabled the facile s..
Engineered Metal-Phenolic Capsules Show Tunable Targeted Delivery to Cancer Cells
Yi Ju, Jiwei Cui, Huanli Sun, Markus Mullner, Yunlu Dai, Junling Guo, Nadja Bertleff-Zieschang, Tomoya Suma, Joseph J Richardson, Frank Caruso
We engineered metal-phenolic capsules with both high targeting and low nonspecific cell binding properties. The capsules were prep..
Thermally Induced Charge Reversal of Layer-by-Layer Assembled Single-Component Polymer Films
Joseph J Richardson, Blaise L Tardy, Hirotaka Ejima, Junling Guo, Jiwei Cui, Kang Liang, Gwan H Choi, Pil J Yoo, Bruno G De Geest, Frank Caruso
Temperature can be harnessed to engineer unique properties for materials useful in various contexts and has been shown to affect t..
Photocontrolled Cargo Release from Dual Cross-Linked Polymer Particles
Shereen Tan, Jiwei Cui, Qiang Fu, Eunhyung Nam, Katharina Ladewig, Jing M Ren, Edgar HH Wong, Frank Caruso, Anton Blencowe, Greg G Qiao
Burst release of a payload from polymeric particles upon photoirradiation was engineered by altering the cross-linking density. Th..
Shape-Dependent Activation of Cytokine Secretion by Polymer Capsules in Human Monocyte-Derived Macrophages
Xi Chen, Yan Yan, Markus Muellner, Yuan Ping, Jiwei Cui, Kristian Kempe, Christina Cortez-Jugo, Frank Caruso
Particles with tailored geometries have received significant attention due to their specific interactions with biological systems...
Assembly-Controlled Permeability of Layer-by-Layer Polymeric Microcapsules Using a Tapered Fluidized Bed
Ka Fung Noi, Ah Roozmand, Mattias Bjoernmalm, Joseph J Richardson, George V Franks, Frank Caruso
Nano- and microcapsules engineered through layer-by-layer (LbL) assembly are finding an increasingly large number of applications ..
Nanoporous Metal–Phenolic Particles as Ultrasound Imaging Probes for Hydrogen Peroxide
J Guo, X Wang, DC Henstridge, JJ Richardson, J Cui, A Sharma, MA Febbraio, K Peter, JB de Haan, CE Hagemeyer, F Caruso
Nanoporous metal-phenolic particles are fabricated through the nanostructural replication of dense FeIII -TA complexes in nanoporo..
Flow-Based Assembly of Layer-by-Layer Capsules through Tangential Flow Filtration
Mattias Bjoernmalm, All Roozmand, Ka Fung Noi, Junling Guo, Jiwei Cui, Joseph J Richardson, Frank Caruso
Layer-by-layer (LbL) assembly on nano- and microparticles is of interest for a range of applications, including catalysis, optics,..
Redox-Sensitive PEG-Polypeptide Nanoporous Particles for Survivin Silencing in Prostate Cancer Cells
Francesca Cavalieri, Giovanni L Beretta, Jiwei Cui, Julia A Braunger, Yan Yan, Joseph J Richardson, Stella Tinelli, Marco Folini, Nadia Zaffaroni, Frank Caruso
We report the engineering of intracellular redox-responsive nanoporous poly(ethylene glycol)-poly(l-lysine) particles (NPEG-PLLs)...
Spatially transformed fluorescence image data for ERK-MAPK and selected proteins within human epidermis
J CURSONS, CE Angel, DG Hurley, CG Print, PR Dunbar, MD Jacobs, EC Crampin
BACKGROUND: Phosphoprotein signalling pathways have been intensively studied in vitro, yet their role in regulating tissue homeost..
Stimulus-dependent differences in signalling regulate epithelial-mesenchymal plasticity and change the effects of drugs in breast cancer cell lines
J Cursons, KJ Leuchowius, M Waltham, E Tomaskovic-Crook, M Foroutan, CP Bracken, A Redfern, EJ Crampin, I Street, MJ Davis, EW Thompson
INTRODUCTION: The normal process of epithelial mesenchymal transition (EMT) is subverted by carcinoma cells to facilitate metastat..
Tuning Particle Biodegradation through Polymer-Peptide Blend Composition
Sylvia T Gunawan, Kristian Kempe, Georgina K Such, Jiwei Cui, Kang Liang, Joseph J Richardson, Angus PR Johnston, Frank Caruso
We report the preparation of polymer-peptide blend replica particles via the mesoporous silica (MS) templated assembly of poly(eth..
Super-Soft Hydrogel Particles with Tunable Elasticity in a Microfluidic Blood Capillary Model
Jiwei Cui, Mattias Bjoernmalm, Kang Liang, Chenglong Xu, James P Best, Xuehua Zhang, Frank Caruso
Super-soft PEG hydrogel particles with tunable elasticity are prepared via a mesoporous silica templating method. The deformabilit..
Convective polymer assembly for the deposition of nanostructures and polymer thin films on immobilized particles
Joseph J Richardson, Mattias Bjoernmalm, Sylvia T Gunawan, Junling Guo, Kang Liang, Blaise Tardy, Shota Sekiguchi, Ka Fung Noi, Jiwei Cui, Hirotaka Ejima, Frank Caruso
We report the preparation of polymer particles via convective polymer assembly (CPA). Convection is used to move polymer solutions..
Mold-Templated Inorganic-Organic Hybrid Supraparticles for Code livery of Drugs
James W Maina, Jiwei Cui, Mattias Bjoernmalm, Andrew K Wise, Robert K Shepherd, Frank Caruso
This paper reports a facile and robust mold-templated technique for the assembly of mesoporous silica (MS) supraparticles and demo..
HIV-specific antibody-dependent phagocytosis matures during HIV infection
Fernanda Ana-Sosa-Batiz, Angus PR Johnston, Haiyin Liu, Robert J Center, Supachai Rerks-Ngarm, Punnee Pitisuttithum, Sorachai Nitayaphan, Jaranit Kaewkungwal, Jerome H Kim, Nelson L Michael, Anthony D Kelleher, Ivan Stratov, Stephen J Kent, Marit Kramski
Antibody-dependent phagocytosis (ADP) is a potentially important immune mechanism to clear HIV. How HIV-specific ADP responses mat..