RECOGNITION OF LIPID ANTIGENS BY THE IMMUNE SYSTEM.

Benzofuran sulfonates and small self-lipid antigens activate type II NKT cells via CD1d

Catarina F Almeida, Dylan GM Smith, Tan-Yun Cheng, Chris M Harpur, Elena Batleska, Catriona V. Nguyen-Robertson, Tram Nguyen, Tamara Thelemann, Scott JJ Reddiex, Shihan Li, Sidonia BG Eckle, Ildiko Van Rhijn, Jamie Rossjohn, Adam P Uldrich, D Branch Moody, Spencer J Williams, Daniel G Pellicci, Dale Godfrey

2021-08-24

Natural killer T (NKT) cells detect lipids presented by CD1d. Most studies focus on type I NKT cells that express semi-invariant α..

Targeting butyrophilins for cancer immunotherapy

Marc Rigau, Adam P Uldrich, Andreas Behren

2021-08-01

Vγ9Vδ2+ T cells form part of the innate immune repertoire and are activated by phosphorylated antigens produced by many bacteria a..

A single-domain bispecific antibody targeting CD1d and the NKT T-cell receptor induces a potent antitumor response

Roeland Lameris, Adam Shahine, Daniel G Pellicci, Adam P Uldrich, Stephanie Gras, Jerome Le Nours, Richard WJ Groen, Jana Vree, Scott JJ Reddiex, Sergio M Quinones-Parra, Stewart K Richardson, Amy R Howell, Sonja Zweegman, Dale I Godfrey, Tanja D de Gruijl, Jamie Rossjohn, Hans J van der Vliet

2020-11-01

Antibody-mediated modulation of major histocompatibility complex (MHC) molecules, or MHC class I-like molecules, could constitute ..

Immune recognition of phosphoantigen-butyrophilin molecular complexes by gamma delta T cells

Adam P Uldrich, Marc Rigau, Dale I Godfrey

2020-10-05

Gamma-delta (γδ) T cells are an important component of the immune system. They are often enriched in non-lymphoid tissues and exhi..

alpha-Glucuronosyl and alpha-glucosyl diacylglycerides, natural killer T cell-activating lipids from bacteria and fungi

Satvika Burugupalli, Catarina F Almeida, Dylan GM Smith, Sayali Shah, Onisha Patel, Jamie Rossjohn, Adam P Uldrich, Dale I Godfrey, Spencer J Williams

2020-02-28

Natural killer T cells express T cell receptors (TCRs) that recognize glycolipid antigens in association with the antigen-presenti..

A class of gamma delta T cell receptors recognize the underside of the antigen-presenting molecule MR1

Jerome Le Nours, Nicholas A Gherardin, Sri H Ramarathinam, Wael Awad, Florian Wiede, Benjamin S Gully, Yogesh Khandokar, T Praveena, Jacinta M Wubben, Jarrod J Sandow, Andrew I Webb, Anouk von Borstel, Michael T Rice, Samuel J Redmond, Rebecca Seneviratna, Maria L Sandoval-Romero, Shihan Li, Michael NT Souter, Sidonia BG Eckle, Alexandra J Corbett

2019-12-20

T cell receptors (TCRs) recognize antigens presented by major histocompatibility complex (MHC) and MHC class I-like molecules. We ..

Distinct CD1d docking strategies exhibited by diverse Type II NKT cell receptors

Catarina F Almeida, Srinivasan Sundararaj, Jerome Le Nours, T Praveena, Benjamin Cao, Satvika Burugupalli, Dylan GM Smith, Onisha Patel, Manfred Brigl, Daniel G Pellicci, Spencer J Williams, Adam P Uldrich, Dale I Godfrey, Jamie Rossjohn

2019-11-20

Type I and type II natural killer T (NKT) cells are restricted to the lipid antigen-presenting molecule CD1d. While we have an und..

Diverse MR1-restricted T cells in mice and humans.

Hui-Fern Koay, Nicholas A Gherardin, Calvin Xu, Rebecca Seneviratna, Zhe Zhao, Zhenjun Chen, David P Fairlie, James McCluskey, Daniel G Pellicci, Adam P Uldrich, Dale I Godfrey

2019-05-21

Mucosal-associated invariant T (MAIT) cells express an invariant TRAV1/TRAJ33 TCR-α chain and are restricted to the MHC-I-like mol..

Human blood MAIT cell subsets defined using MR1 tetramers

Nicholas A Gherardin, Michael NT Souter, Hui-Fern Koay, Kirstie M Mangas, Torsten Seemann, Timothy P Stinear, Sidonia BG Eckle, Stuart P Berzins, Yves d'Udekem, Igor E Konstantinov, David P Fairlie, David S Ritchie, Paul J Neeson, Daniel G Pellicci, Adam P Uldrich, James McCluskey, Dale I Godfrey

2018-05-01

Mucosal-associated invariant T (MAIT) cells represent up to 10% of circulating human T cells. They are usually defined using combi..

γδ T cells producing interleukin-17A regulate adipose regulatory T cell homeostasis and thermogenesis.

Ayano C Kohlgruber, Shani T Gal-Oz, Nelson M LaMarche, Moto Shimazaki, Danielle Duquette, Hui-Fern Koay, Hung N Nguyen, Amir I Mina, Tyler Paras, Ali Tavakkoli, Ulrich von Andrian, Adam P Uldrich, Dale I Godfrey, Alexander S Banks, Tal Shay, Michael B Brenner, Lydia Lynch

2018-05-01

γδ T cells are situated at barrier sites and guard the body from infection and damage. However, little is known about their roles ..

Unconventional T Cell Targets for Cancer Immunotherapy

Dale I Godfrey, Jerome Le Nours, Daniel M Andrews, Adam P Uldrich, Jamie Rossjohn

2018-03-20

Most studies on the immunotherapeutic potential of T cells have focused on CD8 and CD4 T cells that recognize peptide antigens (Ag..

Atypical natural killer T-cell receptor recognition of CD1d-lipid antigens

Jerome Le Nours, T Praveena, Daniel G Pellicci, Nicholas A Gherardin, Fiona J Ross, Ricky T Lim, Gurdyal S Besra, Santosh Keshipeddy, Stewart K Richardson, Amy R Howell, Stephanie Gras, Dale I Godfrey, Jamie Rossjohn, Adam P Uldrich

2016-02-01

Crucial to Natural Killer T (NKT) cell function is the interaction between their T-cell receptor (TCR) and CD1d-antigen complex. H..

Human autoreactive T cells recognize CD1b and phospholipids

Ildiko Van Rhijn, Twan van Berlo, Tamara Hilmenyuk, Tan-Yun Cheng, Benjamin J Wolf, Raju VV Tatituri, Adam P Uldrich, Giorgio Napolitani, Vincenzo Cerundolo, John D Altman, Peter Willemsen, Shouxiong Huang, Jamie Rossjohn, Gurdyal S Besra, Michael B Brenner, Dale I Godfrey, D Branch Moody

2016-01-12

In contrast with the common detection of T cells that recognize MHC, CD1a, CD1c, or CD1d proteins, CD1b autoreactive T cells have ..

Antigen Specificity of Type I NKT Cells Is Governed by TCR beta-Chain Diversity

Garth Cameron, Daniel G Pellicci, Adam P Uldrich, Gurdyal S Besra, Petr Illarionov, Spencer J Williams, Nicole L La Gruta, Jamie Rossjohn, Dale I Godfrey

2015-11-15

NKT cells recognize lipid-based Ags presented by CD1d. Type I NKT cells are often referred to as invariant owing to their mostly i..

The burgeoning family of unconventional T cells

Dale I Godfrey, Adam P Uldrich, James McCluskey, Jamie Rossjohn, D Branch Moody

2015-11-01

While most studies of T lymphocytes have focused on T cells reactive to complexes of peptide and major histocompatibility complex ..

Identification of a Potent Microbial Lipid Antigen for Diverse NKT Cells

Benjamin J Wolf, Raju VV Tatituri, Catarina F Almeida, Jerome Le Nours, Veemal Bhowruth, Darryl Johnson, Adam P Uldrich, Fong-Fu Hsu, Manfred Brigl, Gurdyal S Besra, Jamie Rossjohn, Dale I Godfrey, Michael B Brenner

2015-09-15

Semi-invariant/type I NKT cells are a well-characterized CD1d-restricted T cell subset. The availability of potent Ags and tetrame..

Identification of phenotypically and functionally heterogeneous mouse mucosal-associated invariant T cells using MR1 tetramers

Azad Rahimpour, Hui Fern Koay, Anselm Enders, Rhiannon Clanchy, Sidonia BG Eckle, Bronwyn Meehan, Zhenjun Chen, Belinda Whittle, Ligong Liu, David P Fairlie, Chris C Goodnow, James McCluskey, Jamie Rossjohn, Adam P Uldrich, Daniel G Pellicci, Dale I Godfrey

2015-06-29

Studies on the biology of mucosal-associated invariant T cells (MAIT cells) in mice have been hampered by a lack of specific reage..

The molecular bases of delta/alpha beta T cell-mediated antigen recognition

Daniel G Pellicci, Adam P Uldrich, Jerome Le Nours, Fiona Ross, Eric Chabrol, Sidonia BG Eckle, Renate de Boer, Ricky T Lim, Kirsty McPherson, Gurdyal Besra, Amy R Howell, Lorenzo Moretta, James McCluskey, Mirjam HM Heemskerk, Stephanie Gras, Jamie Rossjohn, Dale I Godfrey

2014-12-15

αβ and γδ T cells are disparate T cell lineages that can respond to distinct antigens (Ags) via the use of the αβ and γδ T cell Ag..