RECOGNITION OF LIPID ANTIGENS BY THE IMMUNE SYSTEM.
Grant number: FT140100278 | Funding period: 2015 - 2019
T cells are a critical component of the immune system, protecting against a range of pathogens by detecting and responding to foreign molecules. Despite their importance, there is still much to learn about how T cells function. New types of T cells that respond to bacteria-derived lipid molecules, have recently been identified. This project aims to undertake a molecular and functional investigation into lipid-reactive T cells. This will provide basic fundamental insight into a poorly understood, but crucial, component of the immune system as well as an opportunity to ultimately develop novel lipid-based vaccines.
Related publications (17)
A single-domain bispecific antibody targeting CD1d and the NKT T-cell receptor induces a potent antitumor response
Roeland Lameris, Adam Shahine, Daniel G Pellicci, Adam P Uldrich, Stephanie Gras, Jerome Le Nours, Richard WJ Groen, Jana Vree, Scott JJ Reddiex, Sergio M Quinones-Parra, Stewart K Richardson, Amy R Howell, Sonja Zweegman, Dale I Godfrey, Tanja D de Gruijl, Jamie Rossjohn, Hans J van der Vliet
Antibody-mediated modulation of major histocompatibility complex (MHC) molecules, or MHC class I-like molecules, could constitute ..
alpha-Glucuronosyl and alpha-glucosyl diacylglycerides, natural killer T cell-activating lipids from bacteria and fungi
Satvika Burugupalli, Catarina F Almeida, Dylan GM Smith, Sayali Shah, Onisha Patel, Jamie Rossjohn, Adam P Uldrich, Dale I Godfrey, Spencer J Williams
Natural killer T cells express T cell receptors (TCRs) that recognize glycolipid antigens in association with the antigen-presenti..
A class of gamma delta T cell receptors recognize the underside of the antigen-presenting molecule MR1
Jerome Le Nours, Nicholas A Gherardin, Sri H Ramarathinam, Wael Awad, Florian Wiede, Benjamin S Gully, Yogesh Khandokar, T Praveena, Jacinta M Wubben, Jarrod J Sandow, Andrew I Webb, Anouk von Borstel, Michael T Rice, Samuel J Redmond, Rebecca Seneviratna, Maria L Sandoval-Romero, Shihan Li, Michael NT Souter, Sidonia BG Eckle, Alexandra J Corbett
T cell receptors (TCRs) recognize antigens presented by major histocompatibility complex (MHC) and MHC class I-like molecules. We ..
Distinct CD1d docking strategies exhibited by diverse Type II NKT cell receptors
Catarina F Almeida, Srinivasan Sundararaj, Jerome Le Nours, T Praveena, Benjamin Cao, Satvika Burugupalli, Dylan GM Smith, Onisha Patel, Manfred Brigl, Daniel G Pellicci, Spencer J Williams, Adam P Uldrich, Dale I Godfrey, Jamie Rossjohn
Type I and type II natural killer T (NKT) cells are restricted to the lipid antigen-presenting molecule CD1d. While we have an und..
Diverse MR1-restricted T cells in mice and humans.
Hui-Fern Koay, Nicholas A Gherardin, Calvin Xu, Rebecca Seneviratna, Zhe Zhao, Zhenjun Chen, David P Fairlie, James McCluskey, Daniel G Pellicci, Adam P Uldrich, Dale I Godfrey
Mucosal-associated invariant T (MAIT) cells express an invariant TRAV1/TRAJ33 TCR-α chain and are restricted to the MHC-I-like mol..
Human blood MAIT cell subsets defined using MR1 tetramers
Nicholas A Gherardin, Michael NT Souter, Hui-Fern Koay, Kirstie M Mangas, Torsten Seemann, Timothy P Stinear, Sidonia BG Eckle, Stuart P Berzins, Yves d'Udekem, Igor E Konstantinov, David P Fairlie, David S Ritchie, Paul J Neeson, Daniel G Pellicci, Adam P Uldrich, James McCluskey, Dale I Godfrey
Mucosal-associated invariant T (MAIT) cells represent up to 10% of circulating human T cells. They are usually defined using combi..
γδ T cells producing interleukin-17A regulate adipose regulatory T cell homeostasis and thermogenesis.
Ayano C Kohlgruber, Shani T Gal-Oz, Nelson M LaMarche, Moto Shimazaki, Danielle Duquette, Hui-Fern Koay, Hung N Nguyen, Amir I Mina, Tyler Paras, Ali Tavakkoli, Ulrich von Andrian, Adam P Uldrich, Dale I Godfrey, Alexander S Banks, Tal Shay, Michael B Brenner, Lydia Lynch
γδ T cells are situated at barrier sites and guard the body from infection and damage. However, little is known about their roles ..
Atypical natural killer T-cell receptor recognition of CD1d-lipid antigens
Jerome Le Nours, T Praveena, Daniel G Pellicci, Nicholas A Gherardin, Fiona J Ross, Ricky T Lim, Gurdyal S Besra, Santosh Keshipeddy, Stewart K Richardson, Amy R Howell, Stephanie Gras, Dale I Godfrey, Jamie Rossjohn, Adam P Uldrich
Crucial to Natural Killer T (NKT) cell function is the interaction between their T-cell receptor (TCR) and CD1d-antigen complex. H..
Human autoreactive T cells recognize CD1b and phospholipids
Ildiko Van Rhijn, Twan van Berlo, Tamara Hilmenyuk, Tan-Yun Cheng, Benjamin J Wolf, Raju VV Tatituri, Adam P Uldrich, Giorgio Napolitani, Vincenzo Cerundolo, John D Altman, Peter Willemsen, Shouxiong Huang, Jamie Rossjohn, Gurdyal S Besra, Michael B Brenner, Dale I Godfrey, D Branch Moody
In contrast with the common detection of T cells that recognize MHC, CD1a, CD1c, or CD1d proteins, CD1b autoreactive T cells have ..
Antigen Specificity of Type I NKT Cells Is Governed by TCR beta-Chain Diversity
Garth Cameron, Daniel G Pellicci, Adam P Uldrich, Gurdyal S Besra, Petr Illarionov, Spencer J Williams, Nicole L La Gruta, Jamie Rossjohn, Dale I Godfrey
NKT cells recognize lipid-based Ags presented by CD1d. Type I NKT cells are often referred to as invariant owing to their mostly i..
Identification of a Potent Microbial Lipid Antigen for Diverse NKT Cells
Benjamin J Wolf, Raju VV Tatituri, Catarina F Almeida, Jerome Le Nours, Veemal Bhowruth, Darryl Johnson, Adam P Uldrich, Fong-Fu Hsu, Manfred Brigl, Gurdyal S Besra, Jamie Rossjohn, Dale I Godfrey, Michael B Brenner
Semi-invariant/type I NKT cells are a well-characterized CD1d-restricted T cell subset. The availability of potent Ags and tetrame..
Identification of phenotypically and functionally heterogeneous mouse mucosal-associated invariant T cells using MR1 tetramers
Azad Rahimpour, Hui Fern Koay, Anselm Enders, Rhiannon Clanchy, Sidonia BG Eckle, Bronwyn Meehan, Zhenjun Chen, Belinda Whittle, Ligong Liu, David P Fairlie, Chris C Goodnow, James McCluskey, Jamie Rossjohn, Adam P Uldrich, Daniel G Pellicci, Dale I Godfrey
Studies on the biology of mucosal-associated invariant T cells (MAIT cells) in mice have been hampered by a lack of specific reage..
The molecular bases of delta/alpha beta T cell-mediated antigen recognition
Daniel G Pellicci, Adam P Uldrich, Jerome Le Nours, Fiona Ross, Eric Chabrol, Sidonia BG Eckle, Renate de Boer, Ricky T Lim, Kirsty McPherson, Gurdyal Besra, Amy R Howell, Lorenzo Moretta, James McCluskey, Mirjam HM Heemskerk, Stephanie Gras, Jamie Rossjohn, Dale I Godfrey
αβ and γδ T cells are disparate T cell lineages that can respond to distinct antigens (Ags) via the use of the αβ and γδ T cell Ag..