Alphaherpesvirus vaccination, recombination and latency; a study in the natural host
Grant number: FT140101287 | Funding period: 2015 - 2019
Attenuated alphaherpesvirus vaccines are used widely in production and companion animals to help control disease. These vaccines help to prevent clinical signs of disease following challenge with virulent viruses. There is also the potential to use these vaccines to help prevent latent herpesvirus infections, and to limit the opportunities for herpesvirus recombination to occur. This would enhance the ability to control disease in animal populations. This project aims to systematically study how vaccines may be used to limit latency and recombination events by studying avian infectious laryngotracheitis virus in the natural host leading to new insights into how vaccines may be used more effi..View full description
Related publications (12)
Attenuated infectious laryngotracheitis virus vaccines differ in their capacity to establish latency in the trigeminal ganglia of specific pathogen free chickens following eye drop inoculation
Dulari S Thilakarathne, Mauricio JC Coppo, Carol A Hartley, Andres Diaz-Mendez, Jose A Quinteros, Omid Fakhri, Paola K Vaz, Joanne M Devlin
Infectious laryngotracheitis (ILT) is a respiratory disease that affects chickens. It is caused by the alphaherpesvirus, infectiou..
Single Nucleotide Polymorphism Genotyping Analysis Shows That Vaccination Can Limit the Number and Diversity of Recombinant Progeny of Infectious Laryngotracheitis Viruses from the United States
Carlos A Loncoman, Carol A Hartley, Mauricio JC Coppo, Glenn F Browning, Gabriela Beltran, Sylva Riblet, Carolina O Freitas, Maricarmen Garcia, Joanne M Devlin
Infectious laryngotracheitis (ILTV; Gallid alphaherpesvirus 1) causes mild to severe respiratory disease in poultry worldwide. Rec..
Replication-independent reduction in the number and diversity of recombinant progeny viruses in chickens vaccinated with an attenuated infectious laryngotracheitis vaccine
Carlos A Loncoman, Carol A Hartley, Mauricio JC Coppo, Glenn F Browning, Jose A Quinteros, Andres Diaz-Mendez, Dulari Thilakarathne, Omid Fakhri, Paola K Vaz, Joanne M Devlin
Recombination is closely linked with virus replication and is an important mechanism that contributes to genome diversification an..
Avian viral surveillance in Victoria, Australia, and detection of two novel avian herpesviruses
Jemima Amery-Gale, Carol A Hartley, Paola K Vaz, Marc S Marenda, Jane Owens, Paul A Eden, Joanne M Devlin
Viruses in avian hosts can pose threats to avian health and some have zoonotic potential. Hospitals that provide veterinary care f..
EIMERIA TAGGARTI N. SP., A NOVEL COCCIDIAN (APICOMPLEXA: EIMERIORINA) IN THE PROSTATE OF AN ANTECHINUS FLAVIPES
J Amery-Gale, JM Devlin, L Tatarczuch, DA Taggart, DJ Schultz, JA Charles, I Beveridge
A novel coccidian species was discovered in the prostate of an Antechinus flavipes (yellow-footed antechinus) in South Australia d..
Genetic Diversity of Infectious Laryngotracheitis Virus during In Vivo Coinfection Parallels Viral Replication and Arises from Recombination Hot Spots within the Genome
Carlos A Loncoman, Carol A Hartley, Mauricio JC Coppo, Paola K Vaz, Andres Diaz-Mendez, Glenn F Browning, Maricarmen Garcia, Stephen Spatz, Joanne M Devlin
Recombination is a feature of many alphaherpesviruses that infect people and animals. Infectious laryngotracheitis virus (ILTV; Ga..
Natural recombination in alphaherpesviruses: Insights into viral evolution through full genome sequencing and sequence analysis
Carlos A Loncoman, Paola K Vaz, Mauricio JC Coppo, Carol A Hartley, Francisco J Morera, Glenn F Browning, Joanne M Devlin
Recombination in alphaherpesviruses was first described more than sixty years ago. Since then, different techniques have been used..
Development and application of a TaqMan single nucleotide polymorphism genotyping assay to study infectious laryngotracheitis virus recombination in the natural host
Carlos A Loncoman, Carol A Hartley, Mauricio JC Coppo, Paola K Vaz, Andres Diaz-Mendez, Glenn F Browning, Sang-won Lee, Joanne M Devlin
To date, recombination between different strains of the avian alphaherpesvirus infectious laryngotracheitis virus (ILTV) has only ..
Low genetic diversity among historical and contemporary clinical isolates of felid herpesvirus 1
Paola K Vaz, Natalie Job, Jacquelyn Horsington, Nino Ficorilli, Michael J Studdert, Carol A Hartley, James R Gilkerson, Glenn F Browning, Joanne M Devlin
BACKGROUND: Felid herpesvirus 1 (FHV-1) causes upper respiratory tract diseases in cats worldwide, including nasal and ocular disc..
Evidence of widespread natural recombination among field isolates of equine herpesvirus 4 but not among field isolates of equine herpesvirus 1
PK Vaz, J Horsington, CA Hartley, GF Browning, NP Ficorilli, MJ Studdert, JR Gilkerson, JM Devlin
Recombination in alphaherpesviruses allows evolution to occur in viruses that have an otherwise stable DNA genome with a low rate ..
Protection Induced in Broiler Chickens following Drinking-Water Delivery of Live Infectious Laryngotracheitis Vaccines against Subsequent Challenge with Recombinant Field Virus
Mesula G Korsa, Glenn F Browning, Mauricio JC Coppo, Alistair R Legione, James R Gilkerson, Amir H Noormohammadi, Paola K Vaz, Sang-Won Lee, Joanne M Devlin, Carol A Hartley
Infectious laryngotracheitis virus (ILTV) causes acute upper respiratory tract disease in chickens. Attenuated live ILTV vaccines ..