ARC CENTRE OF EXCELLENCE IN CONVERGENT BIO–NANO SCIENCE AND TECHNOLOGY
Grant number: CE140100036 | Funding period: 2014 - 2021
The CoE in Convergent Bio-Nano Science &Technology comprises a multi-disciplinary team focused on research aiming to understand and control the interface of materials with biological systems. The Centre will exploit knowledge of the bio-nano interface to design materials that transport and deliver vaccines, drugs and gene therapy agents, and to design new diagnostic agents and devices. Nanomedicines are on the cusp of revolutionizing diagnosis and therapy in many diseases. The CoE will be the focus of bio-nano research activity in Australia, uniting universities, research agencies, institutes and companies. The expected outcomes are better diagnostic and therapeutic tools designed via an..View full description
Related publications (19)
Nanoscale probing and imaging of HIV-1 RNA in cells with a chimeric LNA-DNA sensor
Alessia Amodio, Marco Cassani, Liviana Mummolo, Christina Cortez-Jugo, Sukhvir Kaur Bhangu, Jori Symons, Chantelle L Ahlenstiel, Giancarlo Forte, Francesco Ricci, Anthony D Kelleher, Sharon R Lewin, Francesca Cavalieri, Frank Caruso
Real-time detection and nanoscale imaging of human immunodeficiency virus type 1 ribonucleic acid (HIV-1 RNA) in latently infected..
Luminescent Metal-Phenolic Networks for Multicolor Particle Labeling
Zhixing Lin, Jiajing Zhou, Yijiao Qu, Shuaijun Pan, Yiyuan Han, Rene PM Lafleur, Jingqu Chen, Christina Cortez-Jugo, Joseph J Richardson, Frank Caruso
The development of fluorescence labeling techniques has attracted widespread interest in various fields, including biomedical scie..
Programmable Phototaxis of Metal-Phenolic Particle Microswimmers
Gan Lin, Joseph J Richardson, Heba Ahmed, Quinn A Besford, Andrew J Christofferson, Sebastian Beyer, Zhixing Lin, Amgad R Rezk, Marco Savioli, Jiajing Zhou, Chris F McConville, Christina Cortez-Jugo, Leslie Y Yeo, Frank Caruso
Light-driven directional motion is common in nature but remains a challenge for synthetic microparticles, particularly regarding c..
Polyphenol-Based Nanoparticles for Intracellular Protein Delivery via Competing Supramolecular Interactions
Yiyuan Han, Jiajing Zhou, Yingjie Hu, Zhixing Lin, Yutian Ma, Joseph J Richardson, Frank Caruso
Intracellular delivery of proteins is a promising strategy for regulating cellular behavior and therefore has attracted interest f..
Understanding the Uptake of Nanomedicines at Different Stages of Brain Cancer Using a Modular Nanocarrier Platform and Precision Bispecific Antibodies
Zachary H Houston, Jens Bunt, Kok-Siong Chen, Simon Puttick, Christopher B Howard, Nicholas L Fletcher, Adrian V Fuchs, Jiwei Cui, Yi Ju, Gary Cowin, Xin Song, Andrew W Boyd, Stephen M Mahler, Linda J Richards, Frank Caruso, Kristofer J Thurecht
Increasing accumulation and retention of nanomedicines within tumor tissue is a significant challenge, particularly in the case of..
Physically-plausible modelling of biomolecular systems: A simplified, energy-based model of the mitochondrial electron transport chain
Peter J Gawthrop, Peter Cudmore, Edmund J Crampin
Advances in systems biology and whole-cell modelling demand increasingly comprehensive mathematical models of cellular biochemistr..
Self-assembling influenza nanoparticle vaccines drive extended germinal center activity and memory B cell maturation.
Hannah G Kelly, Hyon-Xhi Tan, Jennifer A Juno, Robyn Esterbauer, Yi Ju, Wenbo Jiang, Verena C Wimmer, Brigette C Duckworth, Joanna R Groom, Frank Caruso, Masaru Kanekiyo, Stephen J Kent, Adam K Wheatley
Protein-based, self-assembling nanoparticles elicit superior immunity compared with soluble protein vaccines, but the immune mecha..
Link between Low-Fouling and Stealth: A Whole Blood Biomolecular Corona and Cellular Association Analysis on Nanoengineered Particles
Alessia CG Weiss, Hannah G Kelly, Matthew Faria, Quinn A Besford, Adam K Wheatley, Ching-Seng Ang, Edmund J Crampin, Frank Caruso, Stephen J Kent
Upon exposure to human blood, nanoengineered particles interact with a multitude of plasma components, resulting in the formation ..
Self-Assembled Metal-Phenolic Networks on Emulsions as Low-Fouling and pH-Responsive Particles
Quinn A Besford, Yi Ju, Ting-Yi Wang, Gyeongwon Yun, PavelV Cherepanov, Christoph E Hagemeyer, Francesca Cavalieri, Frank Caruso
Interfacial self-assembly is a powerful organizational force for fabricating functional nanomaterials, including nanocarriers, for..
Glycogen-nucleic acid constructs for gene silencing in multicellular tumor spheroids
Marcin Wojnilowicz, Quinn A Besford, Yun-Long Wu, Xian Jun Loh, Julia A Braunger, Agata Glab, Christina Cortez-Jugo, Frank Caruso, Francesca Cavalieri
The poor penetration of nanocarrier-siRNA constructs into tumor tissue is a major hurdle for the in vivo efficacy of siRNA therape..
Synthesis of Metal Nanoparticles in Metal-Phenolic Networks: Catalytic and Antimicrobial Applications of Coated Textiles
Gyeongwon Yun, Shuaijun Pan, Ting-Yi Wang, Junling Guo, Joseph J Richardson, Frank Caruso
The synthesis of metal nanoparticle (NP)-coated textiles (nanotextiles) is achieved by a dipping process in water without toxic ch..
Metal-Organic Frameworks for Cell and Virus Biology: A Perspective
Raffaele Ricco, Weibin Liang, Shaobo Li, Jeremiah J Gassensmith, Frank Caruso, Christian Doonan, Paolo Falcaro
Metal-organic frameworks (MOFs) are a class of coordination polymers, consisting of metal ions or clusters linked together by chem..
Templated Polymer Replica Nanoparticles to Facilitate Assessment of Material-Dependent Pharmacokinetics and Biodistribution
Danzi Song, Jiwei Cui, Huanli Sun, Tri-Hung Nguyen, Sheilajen Alcantara, Robert De Rose, Stephen J Kent, Christopher JH Porter, Frank Caruso
Surface modification is frequently used to tailor the interactions of nanoparticles with biological systems. In many cases, the ch..
A Partially Graphitic Mesoporous Carbon Membrane with Three Dimensionally Networked Nanotunnels for Ultrasensitive Electrochemical Detection
Cong Fu, Deliang Yi, Chao Deng, Xingdong Wang, Weijia Zhang, Yi Tang, Frank Caruso, Yajun Wang
A hierarchically porous partially graphitic carbon (HPGC) membrane with three-dimensionally networked nanotunnels is prepared and ..
Stimulus-dependent differences in signalling regulate epithelial-mesenchymal plasticity and change the effects of drugs in breast cancer cell lines
J Cursons, KJ Leuchowius, M Waltham, E Tomaskovic-Crook, M Foroutan, CP Bracken, A Redfern, EJ Crampin, I Street, MJ Davis, EW Thompson
INTRODUCTION: The normal process of epithelial mesenchymal transition (EMT) is subverted by carcinoma cells to facilitate metastat..