ARC CENTRE OF EXCELLENCE IN CONVERGENT BIO–NANO SCIENCE AND TECHNOLOGY

Nanoscale probing and imaging of HIV-1 RNA in cells with a chimeric LNA-DNA sensor

Alessia Amodio, Marco Cassani, Liviana Mummolo, Christina Cortez-Jugo, Sukhvir Kaur Bhangu, Jori Symons, Chantelle L Ahlenstiel, Giancarlo Forte, Francesco Ricci, Anthony D Kelleher, Sharon R Lewin, Francesca Cavalieri, Frank Caruso

2022-01-31

Real-time detection and nanoscale imaging of human immunodeficiency virus type 1 ribonucleic acid (HIV-1 RNA) in latently infected..

Luminescent Metal-Phenolic Networks for Multicolor Particle Labeling

Zhixing Lin, Jiajing Zhou, Yijiao Qu, Shuaijun Pan, Yiyuan Han, Rene PM Lafleur, Jingqu Chen, Christina Cortez-Jugo, Joseph J Richardson, Frank Caruso

2021-11-15

The development of fluorescence labeling techniques has attracted widespread interest in various fields, including biomedical scie..

Programmable Phototaxis of Metal-Phenolic Particle Microswimmers

Gan Lin, Joseph J Richardson, Heba Ahmed, Quinn A Besford, Andrew J Christofferson, Sebastian Beyer, Zhixing Lin, Amgad R Rezk, Marco Savioli, Jiajing Zhou, Chris F McConville, Christina Cortez-Jugo, Leslie Y Yeo, Frank Caruso

2021-02-26

Light-driven directional motion is common in nature but remains a challenge for synthetic microparticles, particularly regarding c..

Polyphenol-Based Nanoparticles for Intracellular Protein Delivery via Competing Supramolecular Interactions

Yiyuan Han, Jiajing Zhou, Yingjie Hu, Zhixing Lin, Yutian Ma, Joseph J Richardson, Frank Caruso

2020-10-27

Intracellular delivery of proteins is a promising strategy for regulating cellular behavior and therefore has attracted interest f..

Understanding the Uptake of Nanomedicines at Different Stages of Brain Cancer Using a Modular Nanocarrier Platform and Precision Bispecific Antibodies

Zachary H Houston, Jens Bunt, Kok-Siong Chen, Simon Puttick, Christopher B Howard, Nicholas L Fletcher, Adrian V Fuchs, Jiwei Cui, Yi Ju, Gary Cowin, Xin Song, Andrew W Boyd, Stephen M Mahler, Linda J Richards, Frank Caruso, Kristofer J Thurecht

2020-05-27

Increasing accumulation and retention of nanomedicines within tumor tissue is a significant challenge, particularly in the case of..

Physically-plausible modelling of biomolecular systems: A simplified, energy-based model of the mitochondrial electron transport chain

Peter J Gawthrop, Peter Cudmore, Edmund J Crampin

2020-05-21

Advances in systems biology and whole-cell modelling demand increasingly comprehensive mathematical models of cellular biochemistr..

Self-assembling influenza nanoparticle vaccines drive extended germinal center activity and memory B cell maturation.

Hannah G Kelly, Hyon-Xhi Tan, Jennifer A Juno, Robyn Esterbauer, Yi Ju, Wenbo Jiang, Verena C Wimmer, Brigette C Duckworth, Joanna R Groom, Frank Caruso, Masaru Kanekiyo, Stephen J Kent, Adam K Wheatley

2020-05-21

Protein-based, self-assembling nanoparticles elicit superior immunity compared with soluble protein vaccines, but the immune mecha..

Unraveling Biointeractions with Nanoengineered Hydrogel Particles

Frank Caruso

2019-06-03

Oral presentation at Summit on Functional Nanocolloids

Link between Low-Fouling and Stealth: A Whole Blood Biomolecular Corona and Cellular Association Analysis on Nanoengineered Particles

Alessia CG Weiss, Hannah G Kelly, Matthew Faria, Quinn A Besford, Adam K Wheatley, Ching-Seng Ang, Edmund J Crampin, Frank Caruso, Stephen J Kent

2019-05-28

Upon exposure to human blood, nanoengineered particles interact with a multitude of plasma components, resulting in the formation ..

Nebulization of Phenolic Capsules for Pulmonary Delivery

Christina Cortez-Jugo, Yi Ju, Leslie Yeo, Christoph Hagemeyer, Frank Caruso

2018-11-30

Oral presentation at ARC Centre of Excellence in Convergent Bio-Nano Science and Technology Annual Research Workshop

Self-Assembled Metal-Phenolic Networks on Emulsions as Low-Fouling and pH-Responsive Particles

Quinn A Besford, Yi Ju, Ting-Yi Wang, Gyeongwon Yun, PavelV Cherepanov, Christoph E Hagemeyer, Francesca Cavalieri, Frank Caruso

2018-09-27

Interfacial self-assembly is a powerful organizational force for fabricating functional nanomaterials, including nanocarriers, for..

Glycogen-nucleic acid constructs for gene silencing in multicellular tumor spheroids

Marcin Wojnilowicz, Quinn A Besford, Yun-Long Wu, Xian Jun Loh, Julia A Braunger, Agata Glab, Christina Cortez-Jugo, Frank Caruso, Francesca Cavalieri

2018-09-01

The poor penetration of nanocarrier-siRNA constructs into tumor tissue is a major hurdle for the in vivo efficacy of siRNA therape..

Synthesis of Metal Nanoparticles in Metal-Phenolic Networks: Catalytic and Antimicrobial Applications of Coated Textiles

Gyeongwon Yun, Shuaijun Pan, Ting-Yi Wang, Junling Guo, Joseph J Richardson, Frank Caruso

2018-03-07

The synthesis of metal nanoparticle (NP)-coated textiles (nanotextiles) is achieved by a dipping process in water without toxic ch..

Metal-Organic Frameworks for Cell and Virus Biology: A Perspective

Raffaele Ricco, Weibin Liang, Shaobo Li, Jeremiah J Gassensmith, Frank Caruso, Christian Doonan, Paolo Falcaro

2018-01-01

Metal-organic frameworks (MOFs) are a class of coordination polymers, consisting of metal ions or clusters linked together by chem..

A Decade of the Protein Corona

Pu Chun Ke, Sijie Lin, Wolfgang J Parak, Thomas P Davis, Frank Caruso

2017-12-01

In this Perspective, we reflect on a decade of research on the protein corona and contemplate its broad implications for future sc..

Templated Polymer Replica Nanoparticles to Facilitate Assessment of Material-Dependent Pharmacokinetics and Biodistribution

Danzi Song, Jiwei Cui, Huanli Sun, Tri-Hung Nguyen, Sheilajen Alcantara, Robert De Rose, Stephen J Kent, Christopher JH Porter, Frank Caruso

2017-10-04

Surface modification is frequently used to tailor the interactions of nanoparticles with biological systems. In many cases, the ch..

A Partially Graphitic Mesoporous Carbon Membrane with Three Dimensionally Networked Nanotunnels for Ultrasensitive Electrochemical Detection

Cong Fu, Deliang Yi, Chao Deng, Xingdong Wang, Weijia Zhang, Yi Tang, Frank Caruso, Yajun Wang

2017-06-27

A hierarchically porous partially graphitic carbon (HPGC) membrane with three-dimensionally networked nanotunnels is prepared and ..

The complexities and caveats of lineage tracing in the mammary gland

Anne C Rios, Nai Yang Fu, Joseph Cursons, Geoffrey J Lindeman, Jane E Visvader

2016-11-25

Lineage tracing is increasingly being utilised to probe different cell types that exist within the mammary gland. Whilst this tech..

Stimulus-dependent differences in signalling regulate epithelial-mesenchymal plasticity and change the effects of drugs in breast cancer cell lines

J Cursons, KJ Leuchowius, M Waltham, E Tomaskovic-Crook, M Foroutan, CP Bracken, A Redfern, EJ Crampin, I Street, MJ Davis, EW Thompson

2015-05-15

INTRODUCTION: The normal process of epithelial mesenchymal transition (EMT) is subverted by carcinoma cells to facilitate metastat..