Journal article

Deregulation of TNF expression can also cause heart valve disease

Derek Lacey, Philippe Bouillet

Cytokine | ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD | Published : 2016

Abstract

High levels of the pro-inflammatory cytokine tumour necrosis factor (TNF) have been associated with many diseases including rheumatoid arthritis (RA), ankylosing spondylitis (AS), inflammatory bowel disease (IBD) and psoriasis. Although it has been clear for twenty-five years that TNF plays a major role in RA and AS, two major questions remain unanswered: (1) What mechanism underlies the loss of control of TNF levels in patients? (2) How does TNF exert its detrimental effects? Nonetheless, biological anti-TNF drugs have become the most successful treatment of these conditions with a third of patients entering remission, and the global market for biological TNF inhibitors is now estimated at ..

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Grants

Awarded by Australian NHMRC


Awarded by Leukemia and Lymphoma Society (Specialised Center of Research)


Funding Acknowledgements

This work was supported by the Australian NHMRC (Program Grant 461221, Research Fellowship 1042629), the Leukemia and Lymphoma Society (Specialised Center of Research grant 7015), the Arthritis Australia Zimmer fellowship, and infrastructure support from the NHMRC (IRISS) and the Victorian State Government (OIS).