Challenges and solutions for a rational vaccine design for TB-endemic regions
Uthaman Gowthaman, Khurram Mushtaq, Amabel C Tan, Pradeep K Rai, David C Jackson, Javed N Agrewala
Critical Reviews in Microbiology | TAYLOR & FRANCIS LTD | Published : 2015
Vaccines have been successful for global eradication or control of dreaded diseases such as smallpox, diphtheria, tetanus, yellow fever, whooping cough, polio, and measles. Unfortunately, this success has not been achieved for controlling tuberculosis (TB) worldwide. Bacillus Calmette Guérin (BCG) is the only available vaccine against TB. Paradoxically, BCG has deciphered success in the Western world but has failed in TB-endemic areas. In this article, we highlight and discuss the aspects of immunity responsible for controlling Mycobacterium tuberculosis infection and factors responsible for the failure of BCG in TB-endemic countries. In addition, we also suggest strategies that contribute t..View full abstract
We are thankful to CSIR and DBT, India for financial support. UG, KM, and PKR are recipients of DBT and CSIR fellowships. DCJ and ACT are supported by the National Health and Medical Research Council of Australia.