Targeting oxidant-dependent mechanisms for the treatment of COPD and its comorbidities
Ivan Bernardo, Steven Bozinovski, Ross Vlahos
PHARMACOLOGY & THERAPEUTICS | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2015
Chronic obstructive pulmonary disease (COPD) is an incurable global health burden and is characterised by progressive airflow limitation and loss of lung function. In addition to the pulmonary impact of the disease, COPD patients often develop comorbid diseases such as cardiovascular disease, skeletal muscle wasting, lung cancer and osteoporosis. One key feature of COPD, yet often underappreciated, is the contribution of oxidative stress in the onset and development of the disease. Patients experience an increased burden of oxidative stress due to the combined effects of excess reactive oxygen species (ROS) and nitrogen species (RNS) generation, antioxidant depletion and reduced antioxidant ..View full abstract
Awarded by National Health and Medical Research Council of Australia
The authors wish to thank the National Health and Medical Research Council of Australia for funding support (APP1084627). Also the authors wish to thank Mr Adrian Cajili for preparing the images.