Journal article

Wolff's law in action: a mechanism for early knee osteoarthritis

Andrew J Teichtahl, Anita Wluka, Pushpika Wijethilake, Yuanyuan Wang, Ali Ghasem-Zadeh, Flavia M Cicuttini



There is growing interest in the role of bone in knee osteoarthritis. Bone is a dynamic organ, tightly regulated by a multitude of homeostatic controls, including genetic and environmental factors. One such key environmental regulator of periarticular bone is mechanical stimulation, which, according to Wolff's law, is a key determinant of bone properties. Wolff's law theorizes that repetitive loading of bone will cause adaptive responses enabling the bone to better cope with these loads. Despite being an adaptive response of bone, the remodeling process may inadvertently trigger maladaptive responses in other articular structures. Accumulating evidence at the knee suggests that expanding art..

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University of Melbourne Researchers


Awarded by National Health and Medical Research Council (NHMRC)

Awarded by NHMRC

Funding Acknowledgements

This review received no funding other than salary stipends for co-authors as described below. AJT is the recipient of the National Health and Medical Research Council (NHMRC) Early Career Fellowship (#1073284). AEW and YW are the recipients of an NHMRC Career Development Fellowship (Clinical Level 2 #1063574 and Clinical Level 1 #1065464, respectively).