Journal article

The effect of hyperinsulinaemic-euglycaemic clamp and exercise on bone remodeling markers in obese men

Itamar Levinger, Tara C Brennan-Speranza, George Jerums, Nigel K Stepto, Fabio R Serpiello, Glenn K McConell, Mitchell Anderson, David L Hare, Elizabeth Byrnes, Peter R Ebeling, Ego Seeman

BoneKEy Reports | INT BONE & MINERAL SOC | Published : 2015

Abstract

Bone remodelling markers (BRMs) are suppressed following a glucose load and during glucose infusion. As exercise increases indices of bone health and improves glucose handling, we hypothesised that, at rest, hyperinsulinaemic-euglycaemic clamp will suppress BRMs in obese men and that exercise prior to the clamp will prevent this suppression. Eleven obese nondiabetic men (age 58.1±2.2 years, body mass index=33.1±1.4 kg m(-2) mean±s.e.m.) had a hyperinsulinaemic-euglycaemic clamp (HEC) at rest (Control) and 60 min post exercise (four bouts × 4 min cycling at 95% of hazard ratiopeak). Blood samples were analysed for serum insulin, glucose, bone formation markers, total osteocalcin (tOC) and pro..

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Grants

Awarded by National Heart Foundation of Australia


Awarded by NHMRC


Funding Acknowledgements

Associate Professor IL was supported by Future Leader Fellowship (ID: 100040) from the National Heart Foundation of Australia, and Dr TCB-S was supported by an NHMRC Early Career Research Fellowship (ID: 1013295). This manuscript represents collaboration between The University of Melbourne and Victoria University as part of the Collaborative Research Network (CRN) programme and the University of Sydney.