The effect of hyperinsulinaemic-euglycaemic clamp and exercise on bone remodeling markers in obese men
Itamar Levinger, Tara C Brennan-Speranza, George Jerums, Nigel K Stepto, Fabio R Serpiello, Glenn K McConell, Mitchell Anderson, David L Hare, Elizabeth Byrnes, Peter R Ebeling, Ego Seeman
BoneKEy Reports | INT BONE & MINERAL SOC | Published : 2015
Bone remodelling markers (BRMs) are suppressed following a glucose load and during glucose infusion. As exercise increases indices of bone health and improves glucose handling, we hypothesised that, at rest, hyperinsulinaemic-euglycaemic clamp will suppress BRMs in obese men and that exercise prior to the clamp will prevent this suppression. Eleven obese nondiabetic men (age 58.1±2.2 years, body mass index=33.1±1.4 kg m(-2) mean±s.e.m.) had a hyperinsulinaemic-euglycaemic clamp (HEC) at rest (Control) and 60 min post exercise (four bouts × 4 min cycling at 95% of hazard ratiopeak). Blood samples were analysed for serum insulin, glucose, bone formation markers, total osteocalcin (tOC) and pro..View full abstract
Awarded by National Heart Foundation of Australia
Awarded by NHMRC
Associate Professor IL was supported by Future Leader Fellowship (ID: 100040) from the National Heart Foundation of Australia, and Dr TCB-S was supported by an NHMRC Early Career Research Fellowship (ID: 1013295). This manuscript represents collaboration between The University of Melbourne and Victoria University as part of the Collaborative Research Network (CRN) programme and the University of Sydney.