Simvastatin impairs the induction of pulmonary fibrosis caused by a western style diet: a preliminary study
Peter Kruzliak, David L Hare, Vaclav Zvonicek, Jan Klimas, Anthony Zulli
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE | WILEY | Published : 2015
The role of an atherogenic diet in causing pulmonary fibrosis has received little attention and simvastatin has been shown to reduce pulmonary fibrosis in animal models. To determine if an atherogenic diet can induce pulmonary fibrosis and whether simvastatin treatment is beneficial by up-regulating heat shock protein 70 and 90. New Zealand white rabbits (n = 15) were divided: Group 1 (control); Group 2 (MC) received a normal rabbit diet with 1% methionine plus 0.5% cholesterol (atherogenic diet). Group 3 received the same diet as the MC group plus 5 mg/kg/day simvastatin orally (MCS). After 4 weeks, the lungs were collected and analysed. Picrosirus red staining of lung interstitial collagen..View full abstract
This work was supported by the National Health Medical Research Council and National Heart Foundation of Australia. The authors would like to thank Ms Angela Kourakis and Rajneet Arora for their technical expertise.