Journal article

An rhs Gene Linked to the Second Type VI Secretion Cluster Is a Feature of the Pseudomonas aeruginosa Strain PA14

Cerith Jones, Abderrahman Hachani, Eleni Manoli, Alain Filloux



The type VI secretion system (T6SS) of Gram-negative bacteria has been involved in various processes, notably bacterial competition and eukaryotic cell subversion. Most Pseudomonas aeruginosa strains possess three T6SS gene clusters, but only the function of the first T6SS (H1-T6SS) has been clearly elucidated. It is involved in the secretion of three toxins (Tse1 to -3) that target bacterial competitors. In the case of the H2- and H3-T6SS, no clear function has been assigned, and only one effector has been associated with these systems. Yet the H2-T6SS was proposed to promote P. aeruginosa internalization in nonphagocytic epithelial cells. Although the H2-T6SS genetic organization is conser..

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University of Melbourne Researchers


Awarded by MRC

Awarded by Wellcome Trust

Awarded by Medical Research Council

Funding Acknowledgements

Alain Filloux's work on T6SSs is supported by MRC grants G0800171/ID86344 and MR/K001930/1 and Wellcome Trust grant WT091939. Cerith Jones is supported by a BBSRC fellowship. Abderrahman Hachani is supported by Wellcome Trust grant WT091939, and Eleni Manoli is supported by MRC grant MR/K001930/1.