Loss of Host Type-I IFN Signaling Accelerates Metastasis and Impairs NK-cell Antitumor Function in Multiple Models of Breast Cancer

Jai Rautela; Nikola Baschuk; Clare Y Slaney; Krishnath M Jayatilleke; Kun Xiao; Bradley N Bidwell; Erin C Lucas; Edwin D Hawkins; Peter Lock; Christina S Wong; Weisan Chen; Robin L Anderson; Paul J Hertzog; Daniel M Andrews; Andreas Moeller; Belinda S Parker

Journal article

Loss of Host Type-I IFN Signaling Accelerates Metastasis and Impairs NK-cell Antitumor Function in Multiple Models of Breast Cancer

Jai Rautela, Nikola Baschuk, Clare Y Slaney, Krishnath M Jayatilleke, Kun Xiao, Bradley N Bidwell, Erin C Lucas, Edwin D Hawkins, Peter Lock, Christina S Wong, Weisan Chen, Robin L Anderson, Paul J Hertzog, Daniel M Andrews, Andreas Moeller, Belinda S Parker

Cancer Immunology Research | AMER ASSOC CANCER RESEARCH | Published : 2015

DOI: 10.1158/2326-6066.CIR-15-0065

University of Melbourne Researchers

Clare Slaney Author The Sir Peter MacCallum Department of Oncology

Edwin Hawkins Author Medical Biology (W.E.H.I.)

Jai Rautela Author Medical Biology (W.E.H.I.)

Paul Hertzog Author Microbiology and Immunology

Robin Anderson Author The Sir Peter MacCallum Department of Oncology

Grants

Awarded by National Breast Cancer Foundation

Funding Acknowledgements

This work was supported by grant funding from the Cancer Council Victoria (to B.S. Parker and P.J. Hertzog), the National Health and Medical Research Council (NHMRC; to B.S. Parker and P.J. Hertzog), fellowship support from NHMRC and ARC (to B.S. Parker and P.J. Hertzog), and the National Breast Cancer Foundation [NBCF; fellowships to CYS (co-funded by Cure Cancer Australia), R.L. Anderson, and A. Moller].