Brain regions with abnormal network properties in severe epilepsy of Lennox-Gastaut phenotype: Multivariate analysis of task-free fMRI

Mangor Pedersen; Evan K Curwood; John S Archer; David F Abbott; Graeme D Jackson

Journal article

Brain regions with abnormal network properties in severe epilepsy of Lennox-Gastaut phenotype: Multivariate analysis of task-free fMRI

Mangor Pedersen, Evan K Curwood, John S Archer, David F Abbott, Graeme D Jackson

EPILEPSIA | WILEY | Published : 2015

DOI: 10.1111/epi.13135

Abstract

OBJECTIVE: Lennox-Gastaut syndrome, and the similar but less tightly defined Lennox-Gastaut phenotype, describe patients with severe epilepsy, generalized epileptic discharges, and variable intellectual disability. Our previous functional neuroimaging studies suggest that abnormal diffuse association network activity underlies the epileptic discharges of this clinical phenotype. Herein we use a data-driven multivariate approach to determine the spatial changes in local and global networks of patients with severe epilepsy of the Lennox-Gastaut phenotype. METHODS: We studied 9 adult patients and 14 controls. In 20 min of task-free blood oxygen level-dependent functional magnetic resonance imag..

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University of Melbourne Researchers

David Abbott Author Medicine - Austin Health

John Archer Author Medicine - Austin Health

Graeme Jackson Author Florey Department of Neuroscience and Mental Health

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Grants

Awarded by National Health and Medical Research Council (NHMRC) of Australia

Awarded by NHMRC

Funding Acknowledgements

This study was supported by the National Health and Medical Research Council (NHMRC) of Australia (program grant 628952; project grant 628725). The Florey Institute of Neuroscience and Mental Health acknowledges the strong support from the Victorian Government and in particular the funding from the Operational Infrastructure Support Grant. G Jackson is supported by an NHMRC practitioner fellowship (1060312). M Pedersen is supported by The University of Melbourne scholarships (MIRS & MIFRS).