Nanoporous Metal–Phenolic Particles as Ultrasound Imaging Probes for Hydrogen Peroxide
J Guo, X Wang, DC Henstridge, JJ Richardson, J Cui, A Sharma, MA Febbraio, K Peter, JB de Haan, CE Hagemeyer, F Caruso
Advanced healthcare materials | Wiley: 12 months | Published : 2015
Nanoporous metal-phenolic particles are fabricated through the nanostructural replication of dense FeIII -TA complexes in nanoporous CaCO3 template particles. The particles have potential for the diagnostic detection of endogenous levels of H2 O2 ex vivo and in vivo by ultrasound imaging, which is based on the catalytic activity of the coordinated Fe3+ in the particles to break down H2 O2 to O2 microbubbles.
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Awarded by Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology
Awarded by Australian Research Council under the Australian Laureate Fellowship
This research was conducted and funded by the Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology (project number CE140100036). This work was also supported by the Australian Research Council under the Australian Laureate Fellowship (F.C., FL120100030) and Discovery Project (F.C., DP130101846) schemes, and by project grants (to C.E.H. and K.P.) and a Principal Research Fellowship (to K.P.) from the National Health and Medical Research Council, as well as Fellowships from the National Heart Foundation (Career Development Fellowship to C.E.H. and Postdoctoral Fellowship to X.W.). This research was undertaken using equipment co-funded by the Ian Potter Foundation. The work was also supported in part by the Victorian Government's Operational Infrastructure Support Program. J.G. is grateful for a scholarship under the Chinese government award for outstanding self-financed students abroad by the China Scholarship Council. The authors acknowledge Dr. Derek Yuen (Oxidative Stress, Baker IDI Heart and Diabetes Institute, Australia), Dr. Ming Hu, Dr. Huanli Sun, Dr. Yunlu Dai, Katelyn Gause (Department of Chemical and Biomolecular Engineering, The University of Melbourne, Australia), and Fan Tian (School of Engineering, The University of Melbourne, Australia) for valuable discussions.