Journal article

Menstrual Cycle-Related Variation in Physiological Sleep in Women in the Early Menopausal Transition

Massimiliano de Zambotti, Adrian R Willoughby, Stephanie A Sassoon, Ian M Colrain, Fiona C Baker

The Journal of Clinical Endocrinology & Metabolism | ENDOCRINE SOC | Published : 2015

Abstract

CONTEXT: Most studies show sleep homeostasis and continuity remain stable across the menstrual cycle in young women. The influence of the menstrual cycle on physiological sleep in midlife women is unknown. OBJECTIVE: The objective of the study was to assess the impact of menstrual cycle phase on the polysomnogram and electroencephalographic (EEG) features of sleep in midlife women, accounting for the presence of an insomnia disorder. DESIGN AND PARTICIPANTS: This was a laboratory study of 20 women in the early menopausal transition (48.8 ± 2.9 y), 11 with a Diagnostic and Statistical Manual of Mental Disorders, fourth edition, diagnosis of insomnia, studied on one night each in the follicula..

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Grants

Awarded by National Institutes of Health


Awarded by Eunice Kennedy Shriver National Institute of Child Health and Human Development/National Institutes of Health (National Centers for Translational Research in Reproduction and Infertility)


Awarded by EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT


Awarded by NATIONAL HEART, LUNG, AND BLOOD INSTITUTE


Funding Acknowledgements

This study was supported by National Institutes of Health Grant HL103688 (to F.C.B.). The hormone analysis was conducted by The University of Virginia Center for Research in Reproduction Ligand Assay and Analysis Core, which is supported by the Eunice Kennedy Shriver National Institute of Child Health and Human Development/National Institutes of Health (National Centers for Translational Research in Reproduction and Infertility) Grant P50-HD28934.