Segmental origins of cardiac sympathetic nerve activity in rats
Natasha H Pracejus, David GS Farmer, Robin M McAllen
Autonomic Neuroscience | ELSEVIER SCIENCE BV | Published : 2015
The segmental origins of cardiac sympathetic nerve activity (CSNA) were investigated in 8 urethane-anesthetized, artificially ventilated rats. The left upper thoracic sympathetic chain was exposed retropleurally after removing the heads of the second to fourth ribs. The preganglionic inputs to the chain from segments T1-T3 and the trunk distal to T3 were marked for later sectioning. CSNA was recorded conventionally, amplified, rectified and smoothed. Its mean level was quantified before and after each preganglionic input was cut, usually in rostro-caudal sequence. The level after all inputs were cut (i.e. noise and residual ECG pickup) was subtracted from previous measurements. The signal de..View full abstract
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Awarded by Australian Research Council
Awarded by National Health and Medical Research Council Research Fellowship
We thank David Trevaks for technical assistance. This study was supported by Australian Research Council grant DP 130104661 and by the Victorian Government Operational Infrastructure Support Program. RMcA was supported by a National Health and Medical Research Council Research Fellowship (566667).