Characterization of BRCA1 and BRCA2 mutations in a large United States sample.
Sining Chen, Edwin S Iversen, Tara Friebel, Dianne Finkelstein, Barbara L Weber, Andrea Eisen, Leif E Peterson, Joellen M Schildkraut, Claudine Isaacs, Beth N Peshkin, Camille Corio, Leoni Leondaridis, Gail Tomlinson, Debra Dutson, Rich Kerber, Christopher I Amos, Louise C Strong, Donald A Berry, David M Euhus, Giovanni Parmigiani
Journal of Clinical Oncology | Published : 2006
PURPOSE: An accurate evaluation of the penetrance of BRCA1 and BRCA2 mutations is essential to the identification and clinical management of families at high risk of breast and ovarian cancer. Existing studies have focused on Ashkenazi Jews (AJ) or on families from outside the United States. In this article, we consider the US population using the largest US-based cohort to date of both AJ and non-AJ families. METHODS: We collected 676 AJ families and 1,272 families of other ethnicities through the Cancer Genetics Network. Two hundred eighty-two AJ families were population based, whereas the remainder was collected through counseling clinics. We used a retrospective likelihood approach to co..View full abstract
Awarded by NCI NIH HHS
Awarded by NHLBI NIH HHS