Journal article

Selective Expression of a Sodium Pump Isozyme by Cough Receptors and Evidence for Its Essential Role in Regulating Cough

Stuart B Mazzone, Sandra M Reynolds, Nanako Mori, Marian Kollarik, David G Farmer, Allen C Myers, Brendan J Canning

Journal of Neuroscience | SOC NEUROSCIENCE | Published : 2009

Abstract

We have identified a distinct subtype of airway vagal afferent nerve that plays an essential role in regulating the cough reflex. These afferents are exquisitely sensitive to punctate mechanical stimuli, acid, and decreases in extracellular chloride concentrations, but are insensitive to capsaicin, bradykinin, histamine, adenosine, serotonin, or changes in airway intraluminal pressures. In this study we used intravital imaging, retrograde neuronal tracing, and electrophysiological analyses to characterize the structural basis for their peculiar mechanical sensitivity and to further characterize the regulation of their excitability. In completing these experiments, we uncovered evidence for a..

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Grants

Awarded by National Heart, Lung, and Blood Institute


Awarded by National Health and Medical Research Council of Australia


Awarded by NATIONAL HEART, LUNG, AND BLOOD INSTITUTE


Funding Acknowledgements

This study was funded by the National Institutes of Health, Bethesda, MD ( National Heart, Lung, and Blood Institute Grant HL083192). S. B. M. is a National Health and Medical Research Council of Australia R. D. Wright Fellow (#454776).