Discovery and SAR of novel pyrazolo[1,5-a]pyrimidines as inhibitors of CDK9

Louisa J Phillipson; David H Segal; Tracy L Nero; Michael W Parker; Soo San Wan; Melanie de Silva; Mark A Guthridge; Andrew H Wei; Christopher J Burns

Journal article

Discovery and SAR of novel pyrazolo[1,5-a]pyrimidines as inhibitors of CDK9

Louisa J Phillipson, David H Segal, Tracy L Nero, Michael W Parker, Soo San Wan, Melanie de Silva, Mark A Guthridge, Andrew H Wei, Christopher J Burns

Bioorganic & Medicinal Chemistry | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2015

DOI: 10.1016/j.bmc.2015.08.035

University of Melbourne Researchers

Tracy Nero Author Biochemistry and Molecular Biology

Michael Parker Author Biochemistry and Molecular Biology

Christopher Burns Author Chemistry

David Segal Author Medical Biology (W.E.H.I.)

Grants

Awarded by Australian National Health and Medical Research Council

Funding Acknowledgements

This work is supported by scholarships, fellowships and grants from the Australian National Health and Medical Research Council (Research Fellowship to M.W.P.; Independent Research Institutes Infrastructure Support Scheme Grants 9000220 and 9000225), Victorian State Government Operational Infrastructure Support (OIS) Grants, Australian Cancer Research Foundation, and Dyson Bequest funding (Dunn Fellowship to C.J.B.). We thank Prof. D.C.S. Huang for helpful advice and discussion. Ms. Dana Buczek is acknowledged for analytical support.