Journal article

The effect of dose on the antimalarial efficacy of artemether-lumefantrine: a systematic review and pooled analysis of individual patient data

NM Anstey, RN Price, TME Davis, HA Karunajeewa, I Mueller, HA Karunajeewa, U D'Alessandro, A Massougbodji, F Nikiema, J-B Ouedraogo, H Tinto, I Zongo, J-B Ouedraogo, H Tinto, A Same-Ekobo, M Kone, H Menan, AO Toure, W Yavo, W Yavo Show all

The Lancet Infectious Diseases | ELSEVIER SCI LTD | Published : 2015

Abstract

BACKGROUND: Artemether-lumefantrine is the most widely used artemisinin-based combination therapy for malaria, although treatment failures occur in some regions. We investigated the effect of dosing strategy on efficacy in a pooled analysis from trials done in a wide range of malaria-endemic settings. METHODS: We searched PubMed for clinical trials that enrolled and treated patients with artemether-lumefantrine and were published from 1960 to December, 2012. We merged individual patient data from these trials by use of standardised methods. The primary endpoint was the PCR-adjusted risk of Plasmodium falciparum recrudescence by day 28. Secondary endpoints consisted of the PCR-adjusted risk o..

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