Longitudinal study assessing the return of chloroquine susceptibility of Plasmodium falciparum in isolates from travellers returning from West and Central Africa, 2000-2011
Myriam Gharbi, Jennifer A Flegg, Veronique Hubert, Eric Kendjo, Jessica E Metcalf, Lionel Bertaux, Philippe J Guerin, Jacques Le Bras
MALARIA JOURNAL | BMC | Published : 2013
BACKGROUND: Chloroquine (CQ) was the main malaria therapy worldwide from the 1940s until the 1990s. Following the emergence of CQ-resistant Plasmodium falciparum, most African countries discontinued the use of CQ, and now promote artemisinin-based combination therapy as the first-line treatment. This change was generally initiated during the last decade in West and Central Africa. The aim of this study is to describe the changes in CQ susceptibility in this African region, using travellers returning from this region as a sentinel system. METHODS: The study was conducted by the Malaria National Reference Centre, France. The database collated the pfcrtK76T molecular marker for CQ susceptibilit..View full abstract
We thank Prof Carol Sibley for critical reading of the manuscript. Data for Measure DHS was obtained thanks to USAID and data for MICS was obtained thanks to UNICEF. This study was supported in part by a grant for doctoral studies to M Gharbi from the Doctoral Network of the Ecole des Hautes Etudes en Sante Publique, Rennes, France and a grant for CNRpaludisme from Institut national de Veille Sanitaire, St Maurice, France.