Journal article

Longitudinal study assessing the return of chloroquine susceptibility of Plasmodium falciparum in isolates from travellers returning from West and Central Africa, 2000-2011

Myriam Gharbi, Jennifer A Flegg, Veronique Hubert, Eric Kendjo, Jessica E Metcalf, Lionel Bertaux, Philippe J Guerin, Jacques Le Bras

MALARIA JOURNAL | BMC | Published : 2013

Abstract

BACKGROUND: Chloroquine (CQ) was the main malaria therapy worldwide from the 1940s until the 1990s. Following the emergence of CQ-resistant Plasmodium falciparum, most African countries discontinued the use of CQ, and now promote artemisinin-based combination therapy as the first-line treatment. This change was generally initiated during the last decade in West and Central Africa. The aim of this study is to describe the changes in CQ susceptibility in this African region, using travellers returning from this region as a sentinel system. METHODS: The study was conducted by the Malaria National Reference Centre, France. The database collated the pfcrtK76T molecular marker for CQ susceptibilit..

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University of Melbourne Researchers