Journal article
Obligatory role for B cells in the development of angiotensin II-dependent hypertension
CT Chan, CG Sobey, M Lieu, D Ferens, MM Kett, H Diep, HA Kim, SM Krishnan, CV Lewis, E Salimova, P Tipping, A Vinh, CS Samuel, K Peter, TJ Guzik, TS Kyaw, BH Toh, A Bobik, GR Drummond
Hypertension | Published : 2015
Abstract
Clinical hypertension is associated with raised serum IgG antibodies. However, whether antibodies are causative agents in hypertension remains unknown. We investigated whether hypertension in mice is associated with B-cell activation and IgG production and moreover whether B-cell/IgG deficiency affords protection against hypertension and vascular remodeling. Angiotensin II (Ang II) infusion (0.7 mg/kg per day; 28 days) was associated with (1) a 25% increase in the proportion of splenic B cells expressing the activation marker CD86, (2) an 80% increase in splenic plasma cell numbers, (3) a 500% increase in circulating IgG, and (4) marked IgG accumulation in the aortic adventitia. In B-cell-ac..
View full abstractGrants
Awarded by National Health and Medical Research Council of Australia
Awarded by Senior Research Fellowships from National Health and Medical Research Council of Australia
Awarded by Australian Postgraduate Award
Funding Acknowledgements
This work was supported by grants from the National Health and Medical Research Council of Australia (APP1041326). Drs Drummond, Sobey, Samuel, and Peter were supported by Senior Research Fellowships from the National Health and Medical Research Council of Australia (nos APP1006017, APP1079467, APP1041766, and APP1079492, respectively). C.T. Chan was supported by an Australian Postgraduate Award (no. 5131432).