Journal article

Age Related Macular Degeneration and Total Hip Replacement Due to Osteoarthritis or Fracture: Melbourne Collaborative Cohort Study

Elaine W Chong, Yuanyuan Wang, Liubov D Robman, Khin Zaw Aung, Galina A Makeyeva, Graham G Giles, Stephen Graves, Flavia M Cicuttini, Robyn H Guymer



Osteoarthritis is the leading cause of total hip replacement, accounting for more than 80% of all total hip replacements. Emerging evidence suggests that osteoarthritis has a chronic inflammatory component to its pathogenesis similar to age-related macular degeneration. We evaluated the association between age-related macular degeneration and total hip replacement as proxy for severe osteoarthritis or fractured neck of femur in the Melbourne Collaborative Cohort Study. 20,744 participants had complete data on both age-related macular degeneration assessed from colour fundus photographs taken during 2003-2007 and total hip replacement. Total hip replacements due to hip osteoarthritis and frac..

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Awarded by National Health & Medical Research Council of Australia (NHMRC)

Awarded by American Health Assistance Foundation

Awarded by NHMRC Centre for Clinical Research Excellence Grant

Funding Acknowledgements

Victoria Health, The Cancer Council Victoria and National Health & Medical Research Council of Australia (NHMRC) [Program Grant 209057, Capacity Building Grant 251533 and Enabling Grant 396414] funded the MCCS study. Ophthalmic component was funded by the Ophthalmic Research Institute of Australia and American Health Assistance Foundation # M2008-082. CERA is a recipient of the NHMRC Centre for Clinical Research Excellence Grant [529923] and Operational Infrastructure Support from the Victorian Government. The AOA NJRR is funded by the Commonwealth Department of Health. People support was provided through the NHMRC public health medical scholarship (EC), Novartis Medical Retinal Fellowship (EC), NHMRC Career Development Fellowship (YW, # 1065464), Wagstaff Fellowship (LR), NHMRC Career Development (RG, # 300052) and Practitioner (RG, # 529905) Fellowships. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.