Journal article

The Intolerance of Regulatory Sequence to Genetic Variation Predicts Gene Dosage Sensitivity

Slave Petrovski, Ayal B Gussow, Quanli Wang, Matt Halvorsen, Yujun Han, William H Weir, Andrew S Allen, David B Goldstein

PLOS Genetics | PUBLIC LIBRARY SCIENCE | Published : 2015

University of Melbourne Researchers

Grants

Awarded by NIH NINDS Epi4K Sequencing, Bioinformatics and Biostatistics Core grant


Awarded by National Institute Of Neurological Disorders and Stroke of National Institutes of Health


Awarded by Bryan ADRC


Awarded by SAIC-Frederick, Inc.


Awarded by Henry M. Jackson Foundation


Awarded by NIMH


Awarded by NINDS


Awarded by Center for HIV/AIDS Vaccine Immunology ("CHAVI") from National Institute of Allergy and Infectious Diseases, National Institutes of Health


Funding Acknowledgements

This work was supported in part by Biogen Idec MA and the NIH NINDS Epi4K Sequencing, Bioinformatics and Biostatistics Core grant number U01NS077303. SP is a National Health and Medical Research Council of Australia (NHMRC) (CJ Martin) Early Career Fellow (1035130). ABG is supported by the National Institute Of Neurological Disorders and Stroke of the National Institutes of Health under Award Number F31NS092362. The collection of control samples was funded in part by Bryan ADRC NIA P30 AG028377, an award from SAIC-Frederick, Inc. (M11-074), an award from the Henry M. Jackson Foundation (W81XWH-07-2-0067), NIMH awards RC2MH089915 and K01MH098126, NINDS awards 1RC2NS070342-01 and RC2NS070344, and the Center for HIV/AIDS Vaccine Immunology ("CHAVI") under a grant from the National Institute of Allergy and Infectious Diseases, National Institutes of Health (U01AIO67854). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.