Suppression of inflammatory disease activity in rheumatoid arthritis is associated with improvements in retinal microvascular health
John Hsing-Yih Moi, Lauren AB Hodgson, Ian P Wicks, Tien Yin Wong, Sharon Van Doornum
Rheumatology | OXFORD UNIV PRESS | Published : 2016
OBJECTIVE: To investigate the effect of suppressing inflammation on retinal microvascular health in patients with RA. METHODS: Two groups of patients with RA were recruited and studied concurrently. Group A included patients with moderate to high disease activity [28-joint DAS with CRP (DAS28-CRP) >3.2] requiring treatment escalation, while group B had stable low disease activity (DAS28-CRP ≤3.2) not requiring treatment escalation. Retinal photography was performed at baseline and weeks 6 and 24 in group A and at baseline and week 12 in group B. RESULTS: Group A included 26 patients with a mean age of 50.7 years (s.d. 3.5) and a mean disease duration of 7.1 years (s.d. 8.0). Disease activity..View full abstract
This study was supported by a grant-in-aid from the Walkom Trust.