Journal article

Comparing the effectiveness of selective laser trabeculoplasty with topical medication as initial treatment (the Glaucoma Initial Treatment Study): study protocol for a randomised controlled trial

Ecosse L Lamoureux, Rachel Mcintosh, Marios Constantinou, Eva K Fenwick, Jing Xie, Robert Casson, Eric Finkelstein, Ivan Goldberg, Paul Healey, Ravi Thomas, Ghee Soon Ang, Konrad Pesudovs, Jonathan Crowston

TRIALS | BMC | Published : 2015


BACKGROUND: Glaucoma is the leading cause of irreversible blindness in the world. Estimated to affect 60 million people worldwide, this figure is expected to rise to 80 million by 2020. Untreated, glaucoma leads to visual decay and eventually to blindness, and can significantly reduce quality of life. First-line treatment in patients with primary open-angle glaucoma and exfoliative glaucoma is topical medical therapy with ocular hypotensives as eye drops. However, eye drops have several disadvantages including cost, possible local and systemic side effects, and adherence and perseverance issues. Randomised controlled trials have demonstrated that selective laser trabeculoplasty is equally as..

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Awarded by Australian National Health and Medical Research Council (NHMRC)

Awarded by NHMRC

Awarded by National Health and Medical Research Council of Australia

Funding Acknowledgements

This Randomised Controlled Trial is funded by a Project Grant from the Australian National Health and Medical Research Council (NHMRC # 1009844). CERA receives operational infrastructure support from the Victorian Government. First author ELL is funded by a NHMRC Research Fellowship (# 1045280). Co-author EKF is funded by an NHMRC Early Career Fellowship (# 1072987). Last author JC is funded by an NHMRC Practitioner Fellowship (# 529915) and by the Dorothy Adele Edols Charitable Trust. The following Principle Investigators comprise 'The Glaucoma Initial Treatment Study (GITS) Group': Dr Lance Liu, Dr Jonathan Ruddle, Dr Mark Walland, Professor Anthony Wells, Dr David Manning, Associate Professor Jamie Craig, Associate Professor Jonathan Jackson, Associate Professor Sushil Vasudevan, Associate Professor Jemaima Che Hamzah, Professor Keith Martin, Dr Andrew White. They approved the manuscript before submission.