Differentiation and diversity of subsets in group 1 innate lymphoid cells
Cyril Seillet, Gabrielle T Belz
International Immunology | OXFORD UNIV PRESS | Published : 2016
NK cells were first identified in 1975 and represent the prototypical group 1 innate lymphoid cell (ILC). More recently, the discovery of new members of the ILC family has highlighted the complexity of this innate lymphoid lineage. Importantly, it has been recognized that different subsets exist within the group 1 ILC, which have potential roles in mediating immune protection and immunosurveillance, and in regulating tissue homeostasis and inflammation. Here, we review the developmental relationships between the different group 1 ILC, which have been identified to date and discuss how heterogeneity within this expanding family may have arisen.
Awarded by National Health and Medical Research Council of Australia
Program and project grants from the National Health and Medical Research Council of Australia (1027472 and 1047903); a fellowship from the Australian Research Council; The Victorian State Government Operational Infrastructure Grant.