Journal article

Embryonic Lethality in Homozygous Human Her-2 Transgenic Mice Due to Disruption of the Pds5b Gene

Carmen SM Yong, Janelle Sharkey, Belinda Duscio, Ben Venville, Wei-Zen Wei, Richard F Jones, Clare Y Slaney, Gisela Mir Arnau, Anthony T Papenfuss, Jan Schroeder, Phillip K Darcy, Michael H Kershaw

PLOS ONE | PUBLIC LIBRARY SCIENCE | Published : 2015

Abstract

The development of antigen-targeted therapeutics is dependent on the preferential expression of tumor-associated antigens (TAA) at targetable levels on the tumor. Tumor-associated antigens can be generated de novo or can arise from altered expression of normal basal proteins, such as the up-regulation of human epidermal growth factor receptor 2 (Her2/ErbB2). To properly assess the development of Her2 therapeutics in an immune tolerant model, we previously generated a transgenic mouse model in which expression of the human Her2 protein was present in both the brain and mammary tissue. This mouse model has facilitated the development of Her2 targeted therapies in a clinically relevant and suit..

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Grants

Awarded by Cancer Council of Victoria, Australia


Awarded by National Health and Medical Research Council (NHMRC) of Australia


Awarded by National Health and Medical Research Council (NHMRC) Career Development Fellowship


Awarded by NHMRC Program


Awarded by National Breast Cancer Foundation


Funding Acknowledgements

This work was supported by grants from the Cancer Council of Victoria, Australia (1066554) and the National Health and Medical Research Council (NHMRC) of Australia (1003667). MHK and PKD were supported by Senior Research Fellowships from the NHMRC. ATP was supported by a National Health and Medical Research Council (NHMRC) Career Development Fellowship (1003856), an NHMRC Program Grant (1054618) and benefitted from support by the Victorian State Government Operational Infrastructure Support and Australian Government NHMRC Independent Research Institute Infrastructure Support Scheme. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.