Journal article

Differential Atrophy of Hippocampal Subfields: A Comparative Study of Dementia with Lewy Bodies and Alzheimer Disease

Elijah Mak, Li Su, Guy B Williams, Rosie Watson, Michael Firbank, Andrew Blamire, John O'Brien

American Journal of Geriatric Psychiatry | ELSEVIER SCIENCE INC | Published : 2016

Abstract

OBJECTIVES: Dementia with Lewy bodies (DLB) is characterized by relative preservation of the medial temporal lobe compared with Alzheimer disease (AD). The differential involvement of the hippocampal subfields in both diseases has not been clearly established, however. We aim to investigate hippocampal subfield differences in vivo in a clinical cohort of DLB and AD subjects. METHODS: 104 participants (35 DLBs, 36 ADs, and 35 healthy comparison [HC] subjects) underwent clinical assessment and 3T T1-weighted imaging. A Bayesian model implemented in Freesurfer was used to automatically segment the hippocampus and its subfields. We also examined associations between hippocampal subfields and tes..

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Grants

Awarded by Sir Jules Thorn Charitable Trust


Awarded by Medical Research Council


Funding Acknowledgements

This work was supported by the Sir Jules Thorn Charitable Trust, grant no. 05/JTA, the NIHR Biomedical Research Unit in Dementia and the Biomedical Research Centre awarded to Cambridge University Hospitals NHS Foundation Trust and the University of Cambridge, and the NIHR Biomedical Research Unit in Dementia and the Biomedical Research Centre awarded to Newcastle upon Tyne Hospitals NHS Foundation Trust and the Newcastle University. Elijah Mak was in receipt of a Gates Cambridge PhD studentship and an Alzheimer's Research UK Cambridge Network Award.