Journal article

Rapid cellular uptake of Alzheimer amyloid beta A4 peptide by cultured human neuroblastoma cells

N Ida, CL Masters, K Beyreuther

FEBS LETTERS | ELSEVIER SCIENCE BV | Published : 1996

Abstract

Cerebral deposition of betaA4 (beta-amyloid) peptide is a major pathological feature of Alzheimer's disease. Although the mechanism of betaA4 production from cells has been investigated extensively, so far little is known about the catabolism of the peptide. We report here that the human neuroblastoma cell line SH-SY5Y can rapidly clear betaA4 in the culture medium. The clearance was not due to the degradation by extracellularly released protease, but rather due to intracellular degradation after cellular uptake. This clearance activity was specific to SH-SY5Y cells among several cell types examined. Some of the betaA4-derived peptides lacking the N-terminal part of the molecule were not cat..

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