Journal article

APP T-LYMPHOCYTES SELECTIVELY SORTED TO ENDOMYSIAL TUBES IN POLYMYOSITIS DISPLACE NCAM-EXPRESSING MUSCLE-FIBERS

W SCHUBERT, CL MASTERS, K BEYREUTHER

EUROPEAN JOURNAL OF CELL BIOLOGY | WISSENSCHAFTLICHE VERLAG MBH | Published : 1993

Abstract

The characteristic pathogenic feature of polymyositis (PM) is muscle invasion by T lymphocytes penetrating the basal lamina and displacing the sarcolemma of normal muscle fibers (T cell invasion of endomysial tubes). Active forward movement of these T cells is indicated by cell extensions interdigitating with the muscle fiber surface. Here we describe for the first time high abundance of Alzheimer amyloid protein precursor (APP) in invasive T cells contacting the border of muscle fibers in PM. These are the sites of muscle fiber displacement. The percentage of APP+ T cells at these sites is significantly higher than in other neuromuscular disorders with inflammatory infiltrates suggesting a ..

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