Journal article

AMYLOID A4 PROTEIN AND ITS PRECURSOR IN DOWNS-SYNDROME AND ALZHEIMERS-DISEASE

B RUMBLE, R RETALLACK, C HILBICH, G SIMMS, G MULTHAUP, R MARTINS, A HOCKEY, P MONTGOMERY, K BEYREUTHER, CL MASTERS

New England Journal of Medicine | MASS MEDICAL SOC | Published : 1989

Abstract

In patients with Alzheimer's disease, amyloid fibrils that are aggregates of A4 protein subunits are deposited in the brain. A similar process occurs at an earlier age in persons with Down's syndrome. To investigate the deposition of amyloid in these diseases, we used a radioimmunoassay to measure levels of the amyloid precursor (PreA4) in the serum of 17 patients with Down's syndrome, 15 patients with Alzheimer's disease, and 33 normal elderly controls. The mean (+/- SD) concentration of serum PreA4 was increased 1.5-fold in patients with Down's syndrome (2.49 +/- 1.13 nmol per liter) as compared with that in controls (1.68 +/- 0.49 nmol per liter; P less than 0.007); the levels in patients..

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