SYNTHESIS AND SECRETION OF ALZHEIMER AMYLOID-BETA-A4 PRECURSOR PROTEIN BY STIMULATED HUMAN PERIPHERAL-BLOOD LEUKOCYTES
U MONNING, G KONIG, R PRIOR, H MECHLER, U SCHREITERGASSER, CL MASTERS, K BEYREUTHER
FEBS Letters | ELSEVIER SCIENCE BV | Published : 1990
Alzheimer amyloid precursor proteins (APP) are actively secreted by stimulated human peripheral mononuclear blood leucocytes (PMBLs). Induction of APP transcription, translation and secretion was observed with several T cell mitogens but was highest with phytohemagglutinin. The time course of induction is similar to that reported for IL-2 and IL-2 receptor. We suggest that APP may play an important role in the construction of the immunological network and the differentiation of T cells.