Anti-nuclear, anti-neutrophil cytoplasmic and anti-glomerular basement membrane antibodies in hiv-infected individuals

Abstract

Many autoantibodies have been described in HIV-infected individuals. We have examined the incidence, associations and prognostic significance of anti-nuclear antibodies (ANA), anti-neutrophil cytoplasmic antibodies (ANCA) and anti-glomerular basement membrane (GBM) antibodies in individuals with HIV infections. One hundred and five patients, with asymptomatic infections (n = 37), AIDS-related complex (n = 32) or AIDS (n = 36) were studied. Plasma from 24 of these (23% were postive for ANA: most demonstrated speckled fluorescence (n = 21) and were of low titre (1 + in 18). ANCA were demonstrated by IIF in 18 individuals (17% and all fluorescent patterns were seen; 6 of these plasma were also ..